Concise syntheses of L-α-phosphatidyl-D-myo-inositol 3-phosphate (3- PIP), 5-phosphate (5-PIP), and 3,5-bisphosphate (3,5-PIP2)

J R Falck, U. Murali Krishna, Kishta Reddy Katipally, Jorge H. Capdevila, Emin T. Ulug

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Highly efficient, asymmetric total syntheses of the title phospholipids as well as short chain and crosslinkable aminoether analogs were achieved in five to seven steps from a readily available myo-inositol derivative. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)4271-4275
Number of pages5
JournalTetrahedron Letters
Volume41
Issue number22
DOIs
StatePublished - Jun 8 2000

Keywords

  • Cyclitols
  • Inositols
  • Phospholipids
  • Phosphoramidites

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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