Concomitant use of clopidogrel and proton-pump inhibitor: A reality check

Subhash Banerjee, Ahmad Zankar, Rick Weideman, Bertis Little, Emmanouil S. Brilakis

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

There are emerging reports supporting the fact that proton-pump inhibitors competitively inhibit the metabolism of clopidogrel to its active metabolite and diminish its clinical efficacy, especially in patients on long-term dual antiplatelet therapy. In this article, we examine the current evidence and provide interpretation of the results along with practical recommendations for healthcare providers.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalInterventional Cardiology
Volume2
Issue number2
DOIs
StatePublished - Apr 1 2010

Keywords

  • cardiovascular outcome
  • clopidogrel
  • proton-pump inhibitor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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