Concurrent bevacizumab with a sequential regimen of doxorubicin and cyclophosphamide followed by docetaxel and capecitabine as neoadjuvant therapy for HER2- locally advanced breast cancer: A phase II trial of the NSABP foundation research group

Priya Rastogi, Marc E. Buyse, Sandra M. Swain, Samuel A. Jacobs, André Robidoux, Marcia K. Liepman, Eduardo R. Pajon, Philip A. Dy, Juan G. Posada, Marianne K. Melnik, Fanny Piette, Charles E. Geyer, Elfetherios P. Mamounas, Norman Wolmark

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background: Bevacizumab with chemotherapy improves outcomes in patients with metastatic breast cancer (MBC). The purpose of this trial was to determine the activity and safety profile of neoadjuvant bevacizumab with chemotherapy in women with locally advanced breast cancer (LABC). Methods: Between November 2006 and August 2007, 45 women with HER2- LABC began preoperative standard AC (doxorubicin [Adriamycin], cyclophosphamide) × 4 cycles followed by docetaxel 75 mg/m2 intravenously (I.V.) on day 1 and capecitabine 825 mg/m2 twice daily on days 1-14 (TX, docetaxel [Taxotere] and capecitabine [Xeloda]) every 21 days for 4 cycles. Bevacizumab 15 mg/kg I.V. was given concurrently with chemotherapy every 21 days for a total of 6 preoperative doses. Postoperatively bevacizumab was resumed for a total of 10 doses. The primary endpoint was pathologic complete response (pCR) in the breast. Results: Thirty patients (66.7%) had stage IIIA disease, 12 (26.7%) patients had stage IIIB, and 3 patients (6.7%) had stage IIIC. Of these, 10 (22%) had inflammatory breast cancer (IBC), and 27 (60%) had estrogen receptor (ER)+ disease. A pCR in the breast with negative axillary nodes was documented in 4 (9%) of 45 patients. Toxicities that were seen with AC and bevacizumab included fatigue (grade 2/3; 31% and 9%, respectively), mucositis (grade 2/3; 29% and 2%, respectively), and headache (grade 2/3; 16% and 7%, respectively). Toxicities seen with TX and bevacizumab included mucositis (grade 2/3; 48% and 25%, respectively), fatigue (grade 2/3; 43% and 18%, respectively), and hand-foot syndrome (grade 2/3; 34% and 23%, respectively). Conclusions: This regimen demonstrated only modest activity with substantial toxicity and does not appear to warrant further evaluation.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalClinical breast cancer
Volume11
Issue number4
DOIs
StatePublished - Aug 2011

Keywords

  • Locally advanced breast cancer
  • Neoadjuvant chemotherapy
  • Preoperative chemotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Rastogi, P., Buyse, M. E., Swain, S. M., Jacobs, S. A., Robidoux, A., Liepman, M. K., Pajon, E. R., Dy, P. A., Posada, J. G., Melnik, M. K., Piette, F., Geyer, C. E., Mamounas, E. P., & Wolmark, N. (2011). Concurrent bevacizumab with a sequential regimen of doxorubicin and cyclophosphamide followed by docetaxel and capecitabine as neoadjuvant therapy for HER2- locally advanced breast cancer: A phase II trial of the NSABP foundation research group. Clinical breast cancer, 11(4), 228-234. https://doi.org/10.1016/j.clbc.2011.04.001