Conditional animal models for the study of lipid metabolism and lipid disorders

H. H. Bock, J. Herz, P. May

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

The advent of technologies that allow conditional mutagenesis has revolutionized our ability to explore gene functions and to establish animal models of human diseases. Both aspects have proven to be of particular importance in the study of lipid-related disorders. Classical approaches to gene inactivation by conventional gene targeting strategies have been successfully applied to generate animal models like the LDL receptor- and the apolipoprotein E-knockout mice, which are still widely used to study diverse aspects of atherosclerosis, lipid transport, and neurodegenerative disease. In many cases, however, simply inactivating the gene of interest has resulted in early lethal or complex phenotypes which are difficult to interpret. In recent years, additional tools have therefore been developed that allow the spatiotemporally controlled manipulation of the genome, as described in detail in Part I of this volume. Our aim is to provide an exemplary survey of the application of different conditional mutagenesis techniques in lipid research in order to illustrate their potential to unravel physiological functions of a broad range of genes involved in lipid homeostasis.

Original languageEnglish (US)
Title of host publicationHandbook of Experimental Pharmacology
Pages407-439
Number of pages33
Volume178
DOIs
StatePublished - 2007

Publication series

NameHandbook of Experimental Pharmacology
Volume178
ISSN (Print)01712004
ISSN (Electronic)18650325

Fingerprint

Lipid Metabolism Disorders
Animals
Animal Models
Genes
Lipids
Mutagenesis
Animal Disease Models
Gene Targeting
LDL Receptors
Gene Silencing
Apolipoproteins E
Knockout Mice
Neurodegenerative Diseases
Neurodegenerative diseases
Atherosclerosis
Homeostasis
Genome
Technology
Phenotype
Lipid Metabolism

Keywords

  • Atherosclerosis
  • Lipoprotein
  • LRP
  • PPAR
  • SREBP

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry
  • Medicine(all)

Cite this

Bock, H. H., Herz, J., & May, P. (2007). Conditional animal models for the study of lipid metabolism and lipid disorders. In Handbook of Experimental Pharmacology (Vol. 178, pp. 407-439). (Handbook of Experimental Pharmacology; Vol. 178). https://doi.org/10.1007/978-3-540-35109-2-17

Conditional animal models for the study of lipid metabolism and lipid disorders. / Bock, H. H.; Herz, J.; May, P.

Handbook of Experimental Pharmacology. Vol. 178 2007. p. 407-439 (Handbook of Experimental Pharmacology; Vol. 178).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bock, HH, Herz, J & May, P 2007, Conditional animal models for the study of lipid metabolism and lipid disorders. in Handbook of Experimental Pharmacology. vol. 178, Handbook of Experimental Pharmacology, vol. 178, pp. 407-439. https://doi.org/10.1007/978-3-540-35109-2-17
Bock HH, Herz J, May P. Conditional animal models for the study of lipid metabolism and lipid disorders. In Handbook of Experimental Pharmacology. Vol. 178. 2007. p. 407-439. (Handbook of Experimental Pharmacology). https://doi.org/10.1007/978-3-540-35109-2-17
Bock, H. H. ; Herz, J. ; May, P. / Conditional animal models for the study of lipid metabolism and lipid disorders. Handbook of Experimental Pharmacology. Vol. 178 2007. pp. 407-439 (Handbook of Experimental Pharmacology).
@inbook{16829d38cc5f42b8aa06d1d96e680419,
title = "Conditional animal models for the study of lipid metabolism and lipid disorders",
abstract = "The advent of technologies that allow conditional mutagenesis has revolutionized our ability to explore gene functions and to establish animal models of human diseases. Both aspects have proven to be of particular importance in the study of lipid-related disorders. Classical approaches to gene inactivation by conventional gene targeting strategies have been successfully applied to generate animal models like the LDL receptor- and the apolipoprotein E-knockout mice, which are still widely used to study diverse aspects of atherosclerosis, lipid transport, and neurodegenerative disease. In many cases, however, simply inactivating the gene of interest has resulted in early lethal or complex phenotypes which are difficult to interpret. In recent years, additional tools have therefore been developed that allow the spatiotemporally controlled manipulation of the genome, as described in detail in Part I of this volume. Our aim is to provide an exemplary survey of the application of different conditional mutagenesis techniques in lipid research in order to illustrate their potential to unravel physiological functions of a broad range of genes involved in lipid homeostasis.",
keywords = "Atherosclerosis, Lipoprotein, LRP, PPAR, SREBP",
author = "Bock, {H. H.} and J. Herz and P. May",
year = "2007",
doi = "10.1007/978-3-540-35109-2-17",
language = "English (US)",
isbn = "9783540351085",
volume = "178",
series = "Handbook of Experimental Pharmacology",
pages = "407--439",
booktitle = "Handbook of Experimental Pharmacology",

}

TY - CHAP

T1 - Conditional animal models for the study of lipid metabolism and lipid disorders

AU - Bock, H. H.

AU - Herz, J.

AU - May, P.

PY - 2007

Y1 - 2007

N2 - The advent of technologies that allow conditional mutagenesis has revolutionized our ability to explore gene functions and to establish animal models of human diseases. Both aspects have proven to be of particular importance in the study of lipid-related disorders. Classical approaches to gene inactivation by conventional gene targeting strategies have been successfully applied to generate animal models like the LDL receptor- and the apolipoprotein E-knockout mice, which are still widely used to study diverse aspects of atherosclerosis, lipid transport, and neurodegenerative disease. In many cases, however, simply inactivating the gene of interest has resulted in early lethal or complex phenotypes which are difficult to interpret. In recent years, additional tools have therefore been developed that allow the spatiotemporally controlled manipulation of the genome, as described in detail in Part I of this volume. Our aim is to provide an exemplary survey of the application of different conditional mutagenesis techniques in lipid research in order to illustrate their potential to unravel physiological functions of a broad range of genes involved in lipid homeostasis.

AB - The advent of technologies that allow conditional mutagenesis has revolutionized our ability to explore gene functions and to establish animal models of human diseases. Both aspects have proven to be of particular importance in the study of lipid-related disorders. Classical approaches to gene inactivation by conventional gene targeting strategies have been successfully applied to generate animal models like the LDL receptor- and the apolipoprotein E-knockout mice, which are still widely used to study diverse aspects of atherosclerosis, lipid transport, and neurodegenerative disease. In many cases, however, simply inactivating the gene of interest has resulted in early lethal or complex phenotypes which are difficult to interpret. In recent years, additional tools have therefore been developed that allow the spatiotemporally controlled manipulation of the genome, as described in detail in Part I of this volume. Our aim is to provide an exemplary survey of the application of different conditional mutagenesis techniques in lipid research in order to illustrate their potential to unravel physiological functions of a broad range of genes involved in lipid homeostasis.

KW - Atherosclerosis

KW - Lipoprotein

KW - LRP

KW - PPAR

KW - SREBP

UR - http://www.scopus.com/inward/record.url?scp=33846926792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846926792&partnerID=8YFLogxK

U2 - 10.1007/978-3-540-35109-2-17

DO - 10.1007/978-3-540-35109-2-17

M3 - Chapter

C2 - 17203665

AN - SCOPUS:33846926792

SN - 9783540351085

VL - 178

T3 - Handbook of Experimental Pharmacology

SP - 407

EP - 439

BT - Handbook of Experimental Pharmacology

ER -