Confirmation of the utility of fine needle aspiration biopsy of the renal allograft

J. H. Helderman, J. Hernandez, Arthur I Sagalowsky, I. Dawidson, J. Glennie, D. Womble, Robert D Toto, K. Brinker, A. R. Hull

Research output: Contribution to journalArticle

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Abstract

Allograft immunobiologic theory would predict that analysis of immunocompetent cells infiltrating the renal transplant would be most instructive. Recently a new aspiration biopsy technique has been developed to permit such analysis in patients which can be safely and repetitively performed. The clinical utility of such a technique has been tested utilizing a randomized prospective trial in which an aspirate was obtained every other day from the third post-operative day until discharge. Analysis included examination of adequacy criteria and the capacity of pathologic diagnosis to corroborate clinical diagnosis from coded specimens. Ninety-six aspirates from 21 consenting transplant recipients were obtained and analyzed. In 94 instances a clinical diagnosis could be made; 80 aspirates fulfilled adequacy criteria. We found the technqiue to be highly sensitive (≥ 90%) and highly specific (≥ 90%) for the clinical diagnoses of acute allograft rejection, post-operative acute renal failure, cyclosporine toxicity, and normal function. We conclude that the fine needle aspiration technique is an important adjunct to analysis of clinical renal transplantation and offers a major advantage to the clinical scholar in understanding transplant biology.

Original languageEnglish (US)
Pages (from-to)376-381
Number of pages6
JournalKidney International
Volume34
Issue number3
StatePublished - 1988

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Fine Needle Biopsy
Allografts
Kidney
Transplants
Needle Biopsy
Acute Kidney Injury
Kidney Transplantation
Cyclosporine

ASJC Scopus subject areas

  • Nephrology

Cite this

Helderman, J. H., Hernandez, J., Sagalowsky, A. I., Dawidson, I., Glennie, J., Womble, D., ... Hull, A. R. (1988). Confirmation of the utility of fine needle aspiration biopsy of the renal allograft. Kidney International, 34(3), 376-381.

Confirmation of the utility of fine needle aspiration biopsy of the renal allograft. / Helderman, J. H.; Hernandez, J.; Sagalowsky, Arthur I; Dawidson, I.; Glennie, J.; Womble, D.; Toto, Robert D; Brinker, K.; Hull, A. R.

In: Kidney International, Vol. 34, No. 3, 1988, p. 376-381.

Research output: Contribution to journalArticle

Helderman, JH, Hernandez, J, Sagalowsky, AI, Dawidson, I, Glennie, J, Womble, D, Toto, RD, Brinker, K & Hull, AR 1988, 'Confirmation of the utility of fine needle aspiration biopsy of the renal allograft', Kidney International, vol. 34, no. 3, pp. 376-381.
Helderman JH, Hernandez J, Sagalowsky AI, Dawidson I, Glennie J, Womble D et al. Confirmation of the utility of fine needle aspiration biopsy of the renal allograft. Kidney International. 1988;34(3):376-381.
Helderman, J. H. ; Hernandez, J. ; Sagalowsky, Arthur I ; Dawidson, I. ; Glennie, J. ; Womble, D. ; Toto, Robert D ; Brinker, K. ; Hull, A. R. / Confirmation of the utility of fine needle aspiration biopsy of the renal allograft. In: Kidney International. 1988 ; Vol. 34, No. 3. pp. 376-381.
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