The SecA translocation ATPase acts as a molecular motor which drives the translocation of proteins through bacterial membranes. In doing so it undergoes large conformational changes and this flexibility may hinder crystallization of the protein. Stabilization of this protein's conformation and its crystallization have been achieved using high glycerol concentrations.
|Original language||English (US)|
|Number of pages||7|
|Journal||Acta Crystallographica Section D: Biological Crystallography|
|State||Published - Apr 25 2001|
ASJC Scopus subject areas
- Structural Biology