Congenital mesoblastic nephroma: An immunohistochemical and lectin study

Tibor Nadasdy, Jürgen Roth, Debbie L. Johnson, Barbara L. Bane, Arthur Weinberg, Regina Verani, Fred G. Silva

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Eight cases of congenital mesoblastic nephroma (CMN) were examined. Three CMNs were of the classical (typical) variant, two were cellular (atypical), and three showed a mixed pattern. A panel of nephron segment-specific tubular epithelial markers (the lectins Tetragonolobus purpureas, Phaseolus vulgaris erythroagglutinin, and Arachis hypogaea and antibodies to epithelial membrane antigen, cytokeratin, and Tamm-Horsfall protein) were used to differentiate epithelial structures within the tumor. Antibodies against vimentin, desmin, and muscle-specific actin were used as mesenchymal markers. A monoclonal antibody to the long (embryonic) form of polysialic acid (PSA) on the neural cell adhesion molecule was used as a putative renal oncodevelopmental marker. An antibody to proliferating cell nuclear antigen also was applied, which revealed increased proliferative rate in cellular CMNs. In addition to clearly entrapped native renal tubules, CMNs contain tubular structures with immature, dysplastic epithelium and occasional epithelial cell clusters embedded deep within the tumor. These immature tubules and clusters express distal nephron, including collecting duct markers and, occasionally, vimentin and PSA. We propose that these primitive tubules and epithelial structures may originate from the ureteric bud. An epithelial differentiation of the tumor cells also is possible. In one pure cellular CMN and two mixed CMNs the cellular component showed diffuse staining for PSA. The PSA (neural cell adhesion molecule) expression of the cellular component suggests that CMN may originate from the uninduced nephrogenic mesenchyme.

Original languageEnglish (US)
Pages (from-to)413-419
Number of pages7
JournalHuman Pathology
Volume24
Issue number4
DOIs
StatePublished - 1993

Fingerprint

Mesoblastic Nephroma
Lectins
Neural Cell Adhesion Molecules
Nephrons
Vimentin
Antibodies
Uromodulin
Kidney
Mucin-1
Neoplasms
Phaseolus
Desmin
Proliferating Cell Nuclear Antigen
Mesoderm
Keratins
Actins
Cell Differentiation
Epithelium
Epithelial Cells
Monoclonal Antibodies

Keywords

  • congenital mesoblastic nephroma
  • immunohistochemistry
  • lectin histochemistry
  • neural cell adhesion molecule
  • tubules

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Nadasdy, T., Roth, J., Johnson, D. L., Bane, B. L., Weinberg, A., Verani, R., & Silva, F. G. (1993). Congenital mesoblastic nephroma: An immunohistochemical and lectin study. Human Pathology, 24(4), 413-419. https://doi.org/10.1016/0046-8177(93)90090-4

Congenital mesoblastic nephroma : An immunohistochemical and lectin study. / Nadasdy, Tibor; Roth, Jürgen; Johnson, Debbie L.; Bane, Barbara L.; Weinberg, Arthur; Verani, Regina; Silva, Fred G.

In: Human Pathology, Vol. 24, No. 4, 1993, p. 413-419.

Research output: Contribution to journalArticle

Nadasdy, T, Roth, J, Johnson, DL, Bane, BL, Weinberg, A, Verani, R & Silva, FG 1993, 'Congenital mesoblastic nephroma: An immunohistochemical and lectin study', Human Pathology, vol. 24, no. 4, pp. 413-419. https://doi.org/10.1016/0046-8177(93)90090-4
Nadasdy T, Roth J, Johnson DL, Bane BL, Weinberg A, Verani R et al. Congenital mesoblastic nephroma: An immunohistochemical and lectin study. Human Pathology. 1993;24(4):413-419. https://doi.org/10.1016/0046-8177(93)90090-4
Nadasdy, Tibor ; Roth, Jürgen ; Johnson, Debbie L. ; Bane, Barbara L. ; Weinberg, Arthur ; Verani, Regina ; Silva, Fred G. / Congenital mesoblastic nephroma : An immunohistochemical and lectin study. In: Human Pathology. 1993 ; Vol. 24, No. 4. pp. 413-419.
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