Congenital pseudarthrosis of the Tibia

Kelly L. Vander Have, Robert N. Hensinger, Michelle Caird, Charles Johnston, Frances A. Farley

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Congenital pseudarthrosis of the tibia is characterized by anterolateral deformity of the tibia and shortening of the limb. Its etiology remains unclear. Although several classification systems have been proposed, none provides specific guidelines for management. Treatment remains challenging. The goal is to obtain and maintain union while minimizing deformity. The basic biologic considerations with surgical intervention include resection of the pseudarthrosis and bridging of the defect with stable fixation. Intramedullary stabilization, free vascularized fibula, and Ilizarov external fixation are among the most frequently used methods of treatment. In addition, bone morphogenetic protein recently has shown promise. Nevertheless, despite improvements in healing rates with congenital pseudarthrosis of the tibia, the potential for amputation in failed cases persists.

Original languageEnglish (US)
Pages (from-to)228-236
Number of pages9
JournalJournal of the American Academy of Orthopaedic Surgeons
Volume16
Issue number4
StatePublished - Apr 2008

Fingerprint

Pseudarthrosis
Tibia
Bone Morphogenetic Proteins
Fibula
Amputation
Extremities
Guidelines
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Vander Have, K. L., Hensinger, R. N., Caird, M., Johnston, C., & Farley, F. A. (2008). Congenital pseudarthrosis of the Tibia. Journal of the American Academy of Orthopaedic Surgeons, 16(4), 228-236.

Congenital pseudarthrosis of the Tibia. / Vander Have, Kelly L.; Hensinger, Robert N.; Caird, Michelle; Johnston, Charles; Farley, Frances A.

In: Journal of the American Academy of Orthopaedic Surgeons, Vol. 16, No. 4, 04.2008, p. 228-236.

Research output: Contribution to journalArticle

Vander Have, KL, Hensinger, RN, Caird, M, Johnston, C & Farley, FA 2008, 'Congenital pseudarthrosis of the Tibia', Journal of the American Academy of Orthopaedic Surgeons, vol. 16, no. 4, pp. 228-236.
Vander Have KL, Hensinger RN, Caird M, Johnston C, Farley FA. Congenital pseudarthrosis of the Tibia. Journal of the American Academy of Orthopaedic Surgeons. 2008 Apr;16(4):228-236.
Vander Have, Kelly L. ; Hensinger, Robert N. ; Caird, Michelle ; Johnston, Charles ; Farley, Frances A. / Congenital pseudarthrosis of the Tibia. In: Journal of the American Academy of Orthopaedic Surgeons. 2008 ; Vol. 16, No. 4. pp. 228-236.
@article{f7ff2efbfd6243a29f505a7cf3123d90,
title = "Congenital pseudarthrosis of the Tibia",
abstract = "Congenital pseudarthrosis of the tibia is characterized by anterolateral deformity of the tibia and shortening of the limb. Its etiology remains unclear. Although several classification systems have been proposed, none provides specific guidelines for management. Treatment remains challenging. The goal is to obtain and maintain union while minimizing deformity. The basic biologic considerations with surgical intervention include resection of the pseudarthrosis and bridging of the defect with stable fixation. Intramedullary stabilization, free vascularized fibula, and Ilizarov external fixation are among the most frequently used methods of treatment. In addition, bone morphogenetic protein recently has shown promise. Nevertheless, despite improvements in healing rates with congenital pseudarthrosis of the tibia, the potential for amputation in failed cases persists.",
author = "{Vander Have}, {Kelly L.} and Hensinger, {Robert N.} and Michelle Caird and Charles Johnston and Farley, {Frances A.}",
year = "2008",
month = "4",
language = "English (US)",
volume = "16",
pages = "228--236",
journal = "Journal of the American Academy of Orthopaedic Surgeons",
issn = "1067-151X",
publisher = "American Association of Orthopaedic Surgeons",
number = "4",

}

TY - JOUR

T1 - Congenital pseudarthrosis of the Tibia

AU - Vander Have, Kelly L.

AU - Hensinger, Robert N.

AU - Caird, Michelle

AU - Johnston, Charles

AU - Farley, Frances A.

PY - 2008/4

Y1 - 2008/4

N2 - Congenital pseudarthrosis of the tibia is characterized by anterolateral deformity of the tibia and shortening of the limb. Its etiology remains unclear. Although several classification systems have been proposed, none provides specific guidelines for management. Treatment remains challenging. The goal is to obtain and maintain union while minimizing deformity. The basic biologic considerations with surgical intervention include resection of the pseudarthrosis and bridging of the defect with stable fixation. Intramedullary stabilization, free vascularized fibula, and Ilizarov external fixation are among the most frequently used methods of treatment. In addition, bone morphogenetic protein recently has shown promise. Nevertheless, despite improvements in healing rates with congenital pseudarthrosis of the tibia, the potential for amputation in failed cases persists.

AB - Congenital pseudarthrosis of the tibia is characterized by anterolateral deformity of the tibia and shortening of the limb. Its etiology remains unclear. Although several classification systems have been proposed, none provides specific guidelines for management. Treatment remains challenging. The goal is to obtain and maintain union while minimizing deformity. The basic biologic considerations with surgical intervention include resection of the pseudarthrosis and bridging of the defect with stable fixation. Intramedullary stabilization, free vascularized fibula, and Ilizarov external fixation are among the most frequently used methods of treatment. In addition, bone morphogenetic protein recently has shown promise. Nevertheless, despite improvements in healing rates with congenital pseudarthrosis of the tibia, the potential for amputation in failed cases persists.

UR - http://www.scopus.com/inward/record.url?scp=42449108309&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42449108309&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 228

EP - 236

JO - Journal of the American Academy of Orthopaedic Surgeons

JF - Journal of the American Academy of Orthopaedic Surgeons

SN - 1067-151X

IS - 4

ER -