TY - JOUR
T1 - Congenital self-healing reticulohistiocytosis (Hashimoto-Pritzker disease)
T2 - Ten-year experience at Dallas Children's Medical Center
AU - Kapur, Payal
AU - Erickson, Christof
AU - Rakheja, Dinesh
AU - Carder, Kerry R
AU - Hoang, Mai P.
PY - 2007/2
Y1 - 2007/2
N2 - The real incidence of congenital self-healing reticulohistiocytosis (CSHR) may be underreported because of its high rate of spontaneous resolution and lack of clinical recognition. Currently, there are no criteria other than clinical that can reliably distinguish CSHR from cutaneous involvement by disseminated Langerhans cell histiocytosis (LCH). In this study we investigate the role of E-cadherin, Ki-67, and phosphorylated histone H3 (PHH3) immunohistochemical stains in distinguishing CSHR from disseminated LCH. We found that no significant difference was seen in the histologic features and the expression of E-cadherin, Ki-67, and PHH3 between the two groups; thus supporting the theory that CSHR and LCH represent different ends of a spectrum of the same condition.
AB - The real incidence of congenital self-healing reticulohistiocytosis (CSHR) may be underreported because of its high rate of spontaneous resolution and lack of clinical recognition. Currently, there are no criteria other than clinical that can reliably distinguish CSHR from cutaneous involvement by disseminated Langerhans cell histiocytosis (LCH). In this study we investigate the role of E-cadherin, Ki-67, and phosphorylated histone H3 (PHH3) immunohistochemical stains in distinguishing CSHR from disseminated LCH. We found that no significant difference was seen in the histologic features and the expression of E-cadherin, Ki-67, and PHH3 between the two groups; thus supporting the theory that CSHR and LCH represent different ends of a spectrum of the same condition.
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U2 - 10.1016/j.jaad.2006.09.001
DO - 10.1016/j.jaad.2006.09.001
M3 - Article
C2 - 17224372
AN - SCOPUS:33846076573
SN - 0190-9622
VL - 56
SP - 290
EP - 294
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 2
ER -