Connection between B lymphocyte and osteoclast differentiation pathways

N. Manabe, H. Kawaguchi, H. Chikuda, C. Miyaura, M. Inada, R. Nagai, Y. I. Nabeshima, K. Nakamura, A. M. Sinclair, R. H. Scheuermann, M. Kuro-o

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

Osteoclasts differentiate from the hemopoietic monocyte/macrophage cell lineage in bone marrow through cell-cell interactions between osteoclast progenitors and stromal/osteoblastic cells. Here we show another osteoclast differentiation pathway closely connected with B lymphocyte differentiation. Recently the TNF family molecule osteoclast differentiation factor/receptor activator of NF-κB ligand (ODF/RANKL) was identified as a key membrane-associated factor regulating osteoclast differentiation. We demonstrate that B-lymphoid lineage cells are a major source of endogenous ODF/RANKL in bone marrow and support osteoclast differentiation in vitro. In addition, B-lymphoid lineage cells in earlier developmental stages may hold a potential to differentiate into osteoclasts when stimulated with M-CSF and soluble ODF/RANKL in vitro. B-lymphoid lineage cells may participate in osteoclastogenesis in two ways: they 1) express ODF/RANKL to support osteoclast differentiation, and 2) serve themselves as osteoclast progenitors. Consistent with these observations in vitro, a decrease in osteoclasts is associated with a decrease in B-lymphoid cells in klotho mutant mice (KL-/-), a mouse model for human aging that exhibits reduced turnover during bone metabolism, rather than a decrease in the differentiation potential of osteoclast progenitors. Taken together, B-lymphoid lineage cells may affect the pathophysiology of bone disorders through regulating osteoclastogenesis.

Original languageEnglish (US)
Pages (from-to)2625-2631
Number of pages7
JournalJournal of Immunology
Volume167
Issue number5
StatePublished - Sep 1 2001

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Osteoclasts
B-Lymphocytes
Lymphocytes
RANK Ligand
Osteogenesis
Macrophage Colony-Stimulating Factor
Bone Remodeling
Cell Lineage
Stromal Cells
Cell Communication
Bone Marrow Cells
Monocytes
Bone Marrow
Macrophages
Ligands
Bone and Bones
Membranes

ASJC Scopus subject areas

  • Immunology

Cite this

Manabe, N., Kawaguchi, H., Chikuda, H., Miyaura, C., Inada, M., Nagai, R., ... Kuro-o, M. (2001). Connection between B lymphocyte and osteoclast differentiation pathways. Journal of Immunology, 167(5), 2625-2631.

Connection between B lymphocyte and osteoclast differentiation pathways. / Manabe, N.; Kawaguchi, H.; Chikuda, H.; Miyaura, C.; Inada, M.; Nagai, R.; Nabeshima, Y. I.; Nakamura, K.; Sinclair, A. M.; Scheuermann, R. H.; Kuro-o, M.

In: Journal of Immunology, Vol. 167, No. 5, 01.09.2001, p. 2625-2631.

Research output: Contribution to journalArticle

Manabe, N, Kawaguchi, H, Chikuda, H, Miyaura, C, Inada, M, Nagai, R, Nabeshima, YI, Nakamura, K, Sinclair, AM, Scheuermann, RH & Kuro-o, M 2001, 'Connection between B lymphocyte and osteoclast differentiation pathways', Journal of Immunology, vol. 167, no. 5, pp. 2625-2631.
Manabe N, Kawaguchi H, Chikuda H, Miyaura C, Inada M, Nagai R et al. Connection between B lymphocyte and osteoclast differentiation pathways. Journal of Immunology. 2001 Sep 1;167(5):2625-2631.
Manabe, N. ; Kawaguchi, H. ; Chikuda, H. ; Miyaura, C. ; Inada, M. ; Nagai, R. ; Nabeshima, Y. I. ; Nakamura, K. ; Sinclair, A. M. ; Scheuermann, R. H. ; Kuro-o, M. / Connection between B lymphocyte and osteoclast differentiation pathways. In: Journal of Immunology. 2001 ; Vol. 167, No. 5. pp. 2625-2631.
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