Consanguineous hemolytic uremic syndrome secondary to Escherichia coli O157:H7 infection treated with aggressive therapeutic plasma exchange

Katharine A. Downes, Kathleen Allen, Ravindra Sarode, Roslyn Yomtovian

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We describe the successful management of an elderly husband and wife with Escherichia coli O157:H7 associated hemolytic uremic syndrome (HUS) treated with aggressive therapeutic plasma exchange (TPE) with replacement with fresh frozen plasma. Following twelve TPEs (three 1.5 volume; nine 1 volume), the husband's platelet count increased from 45 × 109/L to 183 × 109/L. Following ten 1.5 volume TPEs, the wife's platelet count increased from 30 × 109/L to 193 × 109/L. This is the first known occurrence of E. coli O157:H7 associated HUS in an elderly husband and wife successfully treated with aggressive TPE. We conclude that early, aggressive TPE should be considered and may be life-saving for E coli O157:H7 associated HUS in the elderly.

Original languageEnglish (US)
Pages (from-to)155-156
Number of pages2
JournalJournal of Clinical Apheresis
Volume16
Issue number3
DOIs
StatePublished - Nov 1 2001

Keywords

  • Apheresis
  • E. coli O157:H7
  • Hemolytic Uremic Syndrome (HUS)
  • Shiga-like toxin
  • Therapeutic plasma exchange
  • Verocytotoxin

ASJC Scopus subject areas

  • Hematology

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