Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Lorenzo Galluzzi; Ilio Vitale; Sarah Warren; Sandy Adjemian; Patrizia Agostinis; Aitziber Buqué Martinez; Timothy A. Chan; George Coukos; Sandra Demaria; Eric Deutsch; Dobrin Draganov; Richard L. Edelson; Silvia C. Formenti; Jitka Fucikova; Lucia Gabriele; Udo S. Gaipl; Sofia R. Gameiro; Abhishek D. Garg; Encouse Golden; Jian Han; Kevin J. Harrington; Akseli Hemminki; James W. Hodge; Dewan Md Sakib Hossain; Tim Illidge; Michael Karin; Howard L. Kaufman; Oliver Kepp; Guido Kroemer; Juan Jose Lasarte; Sherene Loi; Michael T. Lotze; Gwenola Manic; Taha Merghoub; Alan A. Melcher; Karen L. Mossman; Felipe Prosper; Øystein Rekdal; Maria Rescigno; Chiara Riganti; Antonella Sistigu; Mark J. Smyth; Radek Spisek; John Stagg; Bryan E. Strauss; Daolin Tang; Kazuki Tatsuno; Stefaan W. Van Gool; Peter Vandenabeele; Takahiro Yamazaki; Dmitriy Zamarin; Laurence Zitvogel; Alessandra Cesano; Francesco M. Marincola

doi:10.1136/jitc-2019-000337

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Lorenzo Galluzzi, Ilio Vitale, Sarah Warren, Sandy Adjemian, Patrizia Agostinis, Aitziber Buqué Martinez, Timothy A. Chan, George Coukos, Sandra Demaria, Eric Deutsch, Dobrin Draganov, Richard L. Edelson, Silvia C. Formenti, Jitka Fucikova, Lucia Gabriele, Udo S. Gaipl, Sofia R. Gameiro, Abhishek D. Garg, Encouse Golden, Jian HanKevin J. Harrington, Akseli Hemminki, James W. Hodge, Dewan Md Sakib Hossain, Tim Illidge, Michael Karin, Howard L. Kaufman, Oliver Kepp, Guido Kroemer, Juan Jose Lasarte, Sherene Loi, Michael T. Lotze, Gwenola Manic, Taha Merghoub, Alan A. Melcher, Karen L. Mossman, Felipe Prosper, Øystein Rekdal, Maria Rescigno, Chiara Riganti, Antonella Sistigu, Mark J. Smyth, Radek Spisek, John Stagg, Bryan E. Strauss, Daolin Tang, Kazuki Tatsuno, Stefaan W. Van Gool, Peter Vandenabeele, Takahiro Yamazaki, Dmitriy Zamarin, Laurence Zitvogel, Alessandra Cesano, Francesco M. Marincola

Research output: Contribution to journal › Review article › peer-review

619 Scopus citations

Abstract

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.

Original language	English (US)
Article number	e000337
Journal	Journal for ImmunoTherapy of Cancer
Volume	8
Issue number	1
DOIs	https://doi.org/10.1136/jitc-2019-000337
State	Published - Mar 9 2020

Keywords

immunology
molecular biology
oncology

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Molecular Medicine
Oncology
Pharmacology
Cancer Research

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10.1136/jitc-2019-000337

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Galluzzi, L., Vitale, I., Warren, S., Adjemian, S., Agostinis, P., Martinez, A. B., Chan, T. A., Coukos, G., Demaria, S., Deutsch, E., Draganov, D., Edelson, R. L., Formenti, S. C., Fucikova, J., Gabriele, L., Gaipl, U. S., Gameiro, S. R., Garg, A. D., Golden, E., ... Marincola, F. M. (2020). Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. Journal for ImmunoTherapy of Cancer, 8(1), Article e000337. https://doi.org/10.1136/jitc-2019-000337

Galluzzi, L, Vitale, I, Warren, S, Adjemian, S, Agostinis, P, Martinez, AB, Chan, TA, Coukos, G, Demaria, S, Deutsch, E, Draganov, D, Edelson, RL, Formenti, SC, Fucikova, J, Gabriele, L, Gaipl, US, Gameiro, SR, Garg, AD, Golden, E, Han, J, Harrington, KJ, Hemminki, A, Hodge, JW, Hossain, DMS, Illidge, T, Karin, M, Kaufman, HL, Kepp, O, Kroemer, G, Lasarte, JJ, Loi, S, Lotze, MT, Manic, G, Merghoub, T, Melcher, AA, Mossman, KL, Prosper, F, Rekdal, Ø, Rescigno, M, Riganti, C, Sistigu, A, Smyth, MJ, Spisek, R, Stagg, J, Strauss, BE, Tang, D, Tatsuno, K, Van Gool, SW, Vandenabeele, P, Yamazaki, T, Zamarin, D, Zitvogel, L, Cesano, A & Marincola, FM 2020, 'Consensus guidelines for the definition, detection and interpretation of immunogenic cell death', Journal for ImmunoTherapy of Cancer, vol. 8, no. 1, e000337. https://doi.org/10.1136/jitc-2019-000337

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title = "Consensus guidelines for the definition, detection and interpretation of immunogenic cell death",

abstract = "Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.",

keywords = "immunology, molecular biology, oncology",

author = "Lorenzo Galluzzi and Ilio Vitale and Sarah Warren and Sandy Adjemian and Patrizia Agostinis and Martinez, {Aitziber Buqu{\'e}} and Chan, {Timothy A.} and George Coukos and Sandra Demaria and Eric Deutsch and Dobrin Draganov and Edelson, {Richard L.} and Formenti, {Silvia C.} and Jitka Fucikova and Lucia Gabriele and Gaipl, {Udo S.} and Gameiro, {Sofia R.} and Garg, {Abhishek D.} and Encouse Golden and Jian Han and Harrington, {Kevin J.} and Akseli Hemminki and Hodge, {James W.} and Hossain, {Dewan Md Sakib} and Tim Illidge and Michael Karin and Kaufman, {Howard L.} and Oliver Kepp and Guido Kroemer and Lasarte, {Juan Jose} and Sherene Loi and Lotze, {Michael T.} and Gwenola Manic and Taha Merghoub and Melcher, {Alan A.} and Mossman, {Karen L.} and Felipe Prosper and {\O}ystein Rekdal and Maria Rescigno and Chiara Riganti and Antonella Sistigu and Smyth, {Mark J.} and Radek Spisek and John Stagg and Strauss, {Bryan E.} and Daolin Tang and Kazuki Tatsuno and {Van Gool}, {Stefaan W.} and Peter Vandenabeele and Takahiro Yamazaki and Dmitriy Zamarin and Laurence Zitvogel and Alessandra Cesano and Marincola, {Francesco M.}",

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year = "2020",

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day = "9",

doi = "10.1136/jitc-2019-000337",

language = "English (US)",

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T1 - Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

AU - Galluzzi, Lorenzo

AU - Vitale, Ilio

AU - Warren, Sarah

AU - Adjemian, Sandy

AU - Agostinis, Patrizia

AU - Martinez, Aitziber Buqué

AU - Chan, Timothy A.

AU - Coukos, George

AU - Demaria, Sandra

AU - Deutsch, Eric

AU - Draganov, Dobrin

AU - Edelson, Richard L.

AU - Formenti, Silvia C.

AU - Fucikova, Jitka

AU - Gabriele, Lucia

AU - Gaipl, Udo S.

AU - Gameiro, Sofia R.

AU - Garg, Abhishek D.

AU - Golden, Encouse

AU - Han, Jian

AU - Harrington, Kevin J.

AU - Hemminki, Akseli

AU - Hodge, James W.

AU - Hossain, Dewan Md Sakib

AU - Illidge, Tim

AU - Karin, Michael

AU - Kaufman, Howard L.

AU - Kepp, Oliver

AU - Kroemer, Guido

AU - Lasarte, Juan Jose

AU - Loi, Sherene

AU - Lotze, Michael T.

AU - Manic, Gwenola

AU - Merghoub, Taha

AU - Melcher, Alan A.

AU - Mossman, Karen L.

AU - Prosper, Felipe

AU - Rekdal, Øystein

AU - Rescigno, Maria

AU - Riganti, Chiara

AU - Sistigu, Antonella

AU - Smyth, Mark J.

AU - Spisek, Radek

AU - Stagg, John

AU - Strauss, Bryan E.

AU - Tang, Daolin

AU - Tatsuno, Kazuki

AU - Van Gool, Stefaan W.

AU - Vandenabeele, Peter

AU - Yamazaki, Takahiro

AU - Zamarin, Dmitriy

AU - Zitvogel, Laurence

AU - Cesano, Alessandra

AU - Marincola, Francesco M.

PY - 2020/3/9

Y1 - 2020/3/9

N2 - Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.

AB - Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.

KW - immunology

KW - molecular biology

KW - oncology

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U2 - 10.1136/jitc-2019-000337

DO - 10.1136/jitc-2019-000337

M3 - Review article

C2 - 32209603

AN - SCOPUS:85081610705

SN - 2051-1426

VL - 8

JO - Journal for ImmunoTherapy of Cancer

JF - Journal for ImmunoTherapy of Cancer

IS - 1

M1 - e000337

ER -

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Abstract

Keywords

ASJC Scopus subject areas

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