Consensus recommendations for use of central venous access devices in haemophilia

Bruce M. Ewenstein, L. A. Valentino, J. M. Journeycake, M. D. Tarantino, A. D. Shapiro, V. S. Blanchette, W. K. Hoots, G. R. Buchanan, M. J. Manco-Johnson, G. E. Rivard, K. L. Miller, S. Geraghty, J. A. Maahs, R. Stuart, T. Dunham, R. J. Navickis

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

Venous access is essential for delivery of haemophilia factor concentrate. Wherever possible, peripheral veins remain the route of choice, and the use of central venous access devices (CVADs) should be limited to cases of clear need in patients with caregivers able to exercise diligence in CVAD care and should continue no longer than necessary. CVADs are of recognized value for repeated administration of coagulation factors in haemophilia, particularly for prophylaxis and immune tolerance therapy and in young children. Evidence to guide best practices has been fragmentary, and standardized methods for CVAD usage have yet to be established. We have developed management recommendations based upon available published evidence as well as extensive clinical experience. These recommendations address patient and CVAD selection; CVAD placement, care and removal; caregiver/pattent guidance; and complications, including infection and thrombosis. In the absence of inhibitors, ports are recommended, primarily because of fewer associated infections than with external catheters. For patients with inhibitors, ports also appear to be associated with fewer infections. Infection is the most frequent complication, and recommendations to prevent and treat infections are supported by extensive clinical data and experience. Strict adherence to handwashing and aseptic technique are essential elements of catheter care. Evidence-based data regarding the detection and treatment of CVAD-related thrombotic complications are limited. Caregiver education is an integral part of CVAD use and the procedural practices of users should be regularly re-assessed. These recommendations provide a basis for sound current CVAD practice and are expected to undergo further refinements as new evidence is compiled and clinical experience is gained.

Original languageEnglish (US)
Pages (from-to)629-648
Number of pages20
JournalHaemophilia
Volume10
Issue number5
DOIs
StatePublished - Sep 1 2004

Keywords

  • Catheterization
  • Central venous
  • Haemophilia A
  • Haemophilia B
  • Infection
  • Practice guidelines
  • Venous thrombosis

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)

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  • Cite this

    Ewenstein, B. M., Valentino, L. A., Journeycake, J. M., Tarantino, M. D., Shapiro, A. D., Blanchette, V. S., Hoots, W. K., Buchanan, G. R., Manco-Johnson, M. J., Rivard, G. E., Miller, K. L., Geraghty, S., Maahs, J. A., Stuart, R., Dunham, T., & Navickis, R. J. (2004). Consensus recommendations for use of central venous access devices in haemophilia. Haemophilia, 10(5), 629-648. https://doi.org/10.1111/j.1365-2516.2004.00943.x