Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus

Dedee F. Murrell, Sarah Dick, A. R. Ahmed, Masayuki Amagai, Maria A. Barnadas, Luca Borradori, Jean Claude Bystryn, Giuseppe Cianchini, Luis Diaz, David Fivenson, Russell Hall, Karen E. Harman, Takashi Hashimoto, Michael Hertl, Nico Hunzelmann, Pilar Iranzo, Pascal Joly, Marcel F. Jonkman, Yasuo Kitajima, Neil J. KormanLinda K. Martin, Daniel Mimouni, Amit G. Pandya, Aimee S. Payne, David Rubenstein, Hiroshi Shimizu, Animesh A. Sinha, David Sirois, Detlef Zillikens, Victoria P. Werth

Research output: Contribution to journalReview article

323 Scopus citations

Abstract

Our scientific knowledge of pemphigus has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have helped to define effective therapies in pemphigus. A major obstacle in comparing therapeutic outcomes between centers is the lack of generally accepted definitions and measurements for the clinical evaluation of patients with pemphigus. Common terms and end points of pemphigus are needed so that experts in the field can accurately measure and assess disease extent, activity, severity, and therapeutic response, and thus facilitate and advance clinical trials. This consensus statement from the International Pemphigus Committee represents 2 years of collaborative efforts to attain mutually acceptable common definitions for pemphigus. These should assist in development of consistent reporting of outcomes in future studies.

Original languageEnglish (US)
Pages (from-to)1043-1046
Number of pages4
JournalJournal of the American Academy of Dermatology
Volume58
Issue number6
DOIs
StatePublished - Jun 1 2008

ASJC Scopus subject areas

  • Dermatology

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    Murrell, D. F., Dick, S., Ahmed, A. R., Amagai, M., Barnadas, M. A., Borradori, L., Bystryn, J. C., Cianchini, G., Diaz, L., Fivenson, D., Hall, R., Harman, K. E., Hashimoto, T., Hertl, M., Hunzelmann, N., Iranzo, P., Joly, P., Jonkman, M. F., Kitajima, Y., ... Werth, V. P. (2008). Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus. Journal of the American Academy of Dermatology, 58(6), 1043-1046. https://doi.org/10.1016/j.jaad.2008.01.012