Conservative fluid therapy in septic shock: An example of targeted therapeutic minimization

Catherine Chen, Marin H. Kollef

Research output: Contribution to journalArticle

9 Scopus citations


Intravenous fluids (IVFs) represent a basic therapeutic intervention utilized in septic shock. Unfortunately, the optimal method for administering IVFs to maximize patient outcomes is unknown. A meta-analysis of four randomized trials of goal-directed therapy did not demonstrate a significant reduction in mortality (odds ratio 0.609; 95% confidence interval 0.363 to 1.020; P = 0.059), whereas 18 trials with historical controls showed a significant increase in survival (odds ratio 0.580; 95% confidence interval 0.501 to 0.672; P < 0.0001). Based on these data, clinicians should be aware of the potential for harm due to the excessive administration of IVFs to patients with septic shock.

Original languageEnglish (US)
Article number481
JournalCritical Care
Issue number4
StatePublished - Aug 29 2014


ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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