Conservative surgery and radiation therapy for macroscopically multiple ipsilateral invasive breast cancers

L. Chinsoo Cho, Neil Senzer, George N. Peters

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Background: The presence of macroscopically multiple ipsilateral invasive breast cancer (MMIIBC) has been considered a contraindication for breast conservation. Early series reported high rates of local recurrence. A treatment regimen was developed to accommodate patient requests for breast conservation in MMIIBC. Methods: We reviewed medical records of the 15 MMIIBC patients who underwent partial mastectomy followed by radiation between 1989 and 1997. All patients had 2 or more separate macroscopic tumors greater than 2 mm in diameter. After tumor excision, all specimens were evaluated; the protocol required surgical margins of at least 2 mm. Results: As of June 2000 (median follow-up 76 months), 14 patients (93%) were alive without evidence of disease. One patient died of systemic disease without local recurrence. Conclusions: In selected cases, the combination of breast conservative surgery and radiation therapy with systemic therapy results in acceptable local-regional control. Patients who present with MMIIBC with clear surgical margins should be considered for breast conservation.

Original languageEnglish (US)
Pages (from-to)650-654
Number of pages5
JournalAmerican journal of surgery
Volume183
Issue number6
DOIs
StatePublished - Jul 15 2002

Keywords

  • Breast conservation
  • Clear surgical margins
  • Multiple ipsilateral invasive breast cancers

ASJC Scopus subject areas

  • Surgery

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