Conserved functions of membrane active GTPases in coated vesicle formation

Thomas J. Pucadyil, Sandra L. Schmid

Research output: Contribution to journalReview article

141 Scopus citations

Abstract

Coated vesicles concentrate and package cargo molecules to mediate their efficient transport between intracellular compartments. Cytosolic coat proteins such as clathrin and adaptor complexes and coat protein complex I (COPI) and COPII self-assemble to deform the membrane and interact directly with cargo molecules to capture them in nascent buds. The guanosine triphosphatases (GTPases) Arf, Sari, and dynamin are core components of the coated vesicle machinery. These GTPases, which associate with and dissociate from donor membranes in a guanosine triphosphate-dependent manner, can also actively remodel membranes. Recent evidence suggests that, although structurally diverse, Arf family GTPases and dynamin may play mechanistically similar roles as fidelity monitors that govern cargo packaging and coated vesicle maturation and as components of the fission machinery to mediate vesicle release.

Original languageEnglish (US)
Pages (from-to)1217-1220
Number of pages4
JournalScience
Volume325
Issue number5945
DOIs
StatePublished - Sep 14 2009

ASJC Scopus subject areas

  • General

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