Considering immunomodulatory therapies in the septic patient: Should apoptosis be a potential therapeutic target?

Andreas Oberholzer, Caroline Oberholzer, Rebecca M. Minter, Lyle L. Moldawer

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Treatment of sepsis and septic shock remains a clinical conundrum. Recent prospective trials with anti-cytokine and anti-inflammatory therapies have shown only modest clinical benefit. The successful treatment of the patient with sepsis syndrome will likely require multi-modal therapies aimed at several of the immunological and physiological disturbances which are occurring simultaneously. Recent studies in experimental animals and critically ill patients have suggested that increased apoptosis of lymphoid organs and some parenchymal tissues may contribute to the immune suppression, anergy and organ system dysfunction. Therapies aimed at inhibiting lymphoid cell apoptosis may contribute to improved outcome, and should be considered in the treatment of hospitalized patients with sepsis syndromes. Although clinical trials with anti-apoptotic agents remain distant due in large part to technical difficulties associated with their administration and tissue targeting, inhibition of lymphocyte apoptosis may be an appropriate therapeutic target for the septic patient.

Original languageEnglish (US)
Pages (from-to)221-224
Number of pages4
JournalImmunology Letters
Volume75
Issue number3
DOIs
StatePublished - Jan 15 2001

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Keywords

  • Apoptosis
  • Sepsis
  • T-cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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