Consolidative or palliative whole brain radiation for secondary CNS diffuse large B-Cell lymphoma

Tyler Walburn, Natalie S. Grover, Colette J. Shen, Raghuveer Ranganathan, Christopher Dittus, Anne W. Beaven, Andrew Z. Wang, Kyle Wang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We analyzed 25 patients receiving whole brain radiation (WBRT) for secondary CNS lymphoma (SCNSL), grouped by consolidative intent (after complete/partial response, n = 13) vs. palliative intent (initial CNS treatment, primary refractory disease, or CNS progression, n = 12). Median WBRT dose for the consolidative and palliative cohorts were 24 Gy and 30 Gy, respectively. For 13 patients receiving consolidative WBRT, median OS was 24 months from WBRT and 2-year OS was 64%. Three patients had CNS relapse at 2, 9, and 24 months after consolidative WBRT. For 12 patients receiving palliative WBRT, median OS was 3 months from WBRT and two-year OS was 8%. All 10 patients with neurologic symptoms had documented improvement. In conclusion, consolidative WBRT after chemotherapy response led to reasonable long-term survival and may be an effective strategy for SCNSL, especially transplant-ineligible patients and/or isolated CNS recurrence. Palliative WBRT effectively improved neurologic symptoms, but survival was usually only months.

Original languageEnglish (US)
Pages (from-to)68-75
Number of pages8
JournalLeukemia and Lymphoma
Volume62
Issue number1
DOIs
StatePublished - 2021
Externally publishedYes

Keywords

  • consolidative
  • diffuse large B-cell lymphoma
  • palliative
  • Secondary CNS lymphoma
  • whole brain radiation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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