TY - JOUR
T1 - Consolidative or palliative whole brain radiation for secondary CNS diffuse large B-Cell lymphoma
AU - Walburn, Tyler
AU - Grover, Natalie S.
AU - Shen, Colette J.
AU - Ranganathan, Raghuveer
AU - Dittus, Christopher
AU - Beaven, Anne W.
AU - Wang, Andrew Z.
AU - Wang, Kyle
N1 - Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - We analyzed 25 patients receiving whole brain radiation (WBRT) for secondary CNS lymphoma (SCNSL), grouped by consolidative intent (after complete/partial response, n = 13) vs. palliative intent (initial CNS treatment, primary refractory disease, or CNS progression, n = 12). Median WBRT dose for the consolidative and palliative cohorts were 24 Gy and 30 Gy, respectively. For 13 patients receiving consolidative WBRT, median OS was 24 months from WBRT and 2-year OS was 64%. Three patients had CNS relapse at 2, 9, and 24 months after consolidative WBRT. For 12 patients receiving palliative WBRT, median OS was 3 months from WBRT and two-year OS was 8%. All 10 patients with neurologic symptoms had documented improvement. In conclusion, consolidative WBRT after chemotherapy response led to reasonable long-term survival and may be an effective strategy for SCNSL, especially transplant-ineligible patients and/or isolated CNS recurrence. Palliative WBRT effectively improved neurologic symptoms, but survival was usually only months.
AB - We analyzed 25 patients receiving whole brain radiation (WBRT) for secondary CNS lymphoma (SCNSL), grouped by consolidative intent (after complete/partial response, n = 13) vs. palliative intent (initial CNS treatment, primary refractory disease, or CNS progression, n = 12). Median WBRT dose for the consolidative and palliative cohorts were 24 Gy and 30 Gy, respectively. For 13 patients receiving consolidative WBRT, median OS was 24 months from WBRT and 2-year OS was 64%. Three patients had CNS relapse at 2, 9, and 24 months after consolidative WBRT. For 12 patients receiving palliative WBRT, median OS was 3 months from WBRT and two-year OS was 8%. All 10 patients with neurologic symptoms had documented improvement. In conclusion, consolidative WBRT after chemotherapy response led to reasonable long-term survival and may be an effective strategy for SCNSL, especially transplant-ineligible patients and/or isolated CNS recurrence. Palliative WBRT effectively improved neurologic symptoms, but survival was usually only months.
KW - Secondary CNS lymphoma
KW - consolidative
KW - diffuse large B-cell lymphoma
KW - palliative
KW - whole brain radiation
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U2 - 10.1080/10428194.2020.1821014
DO - 10.1080/10428194.2020.1821014
M3 - Article
C2 - 32935601
AN - SCOPUS:85091021643
SN - 1042-8194
VL - 62
SP - 68
EP - 75
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 1
ER -