Constant light desynchronizes mammalian clock neurons

Hidenobu Ohta, Shin Yamazaki, Douglas G. McMahon

Research output: Contribution to journalArticle

230 Citations (Scopus)

Abstract

Circadian organization can be disrupted by constant light, resulting in behavioral arrhythmicity or 'splitting' of rhythms of activity and rest. By imaging molecular rhythms of individual clock neurons in explanted mouse clock nuclei, we now find that constant light desynchronizes clock neurons but does not compromise their ability to generate circadian rhythms. Cellular synchrony within clock nuclei is disrupted during arrhythmicity, whereas neurons in the left and right clock nuclei cycle in antiphase during 'splitting.'.

Original languageEnglish (US)
Pages (from-to)267-269
Number of pages3
JournalNature Neuroscience
Volume8
Issue number3
DOIs
StatePublished - Mar 2005

Fingerprint

Neurons
Light
Molecular Imaging
Circadian Rhythm

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Constant light desynchronizes mammalian clock neurons. / Ohta, Hidenobu; Yamazaki, Shin; McMahon, Douglas G.

In: Nature Neuroscience, Vol. 8, No. 3, 03.2005, p. 267-269.

Research output: Contribution to journalArticle

Ohta, Hidenobu ; Yamazaki, Shin ; McMahon, Douglas G. / Constant light desynchronizes mammalian clock neurons. In: Nature Neuroscience. 2005 ; Vol. 8, No. 3. pp. 267-269.
@article{a6fdc856c7cd4497acde985f25e47dbe,
title = "Constant light desynchronizes mammalian clock neurons",
abstract = "Circadian organization can be disrupted by constant light, resulting in behavioral arrhythmicity or 'splitting' of rhythms of activity and rest. By imaging molecular rhythms of individual clock neurons in explanted mouse clock nuclei, we now find that constant light desynchronizes clock neurons but does not compromise their ability to generate circadian rhythms. Cellular synchrony within clock nuclei is disrupted during arrhythmicity, whereas neurons in the left and right clock nuclei cycle in antiphase during 'splitting.'.",
author = "Hidenobu Ohta and Shin Yamazaki and McMahon, {Douglas G.}",
year = "2005",
month = "3",
doi = "10.1038/nn1395",
language = "English (US)",
volume = "8",
pages = "267--269",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Constant light desynchronizes mammalian clock neurons

AU - Ohta, Hidenobu

AU - Yamazaki, Shin

AU - McMahon, Douglas G.

PY - 2005/3

Y1 - 2005/3

N2 - Circadian organization can be disrupted by constant light, resulting in behavioral arrhythmicity or 'splitting' of rhythms of activity and rest. By imaging molecular rhythms of individual clock neurons in explanted mouse clock nuclei, we now find that constant light desynchronizes clock neurons but does not compromise their ability to generate circadian rhythms. Cellular synchrony within clock nuclei is disrupted during arrhythmicity, whereas neurons in the left and right clock nuclei cycle in antiphase during 'splitting.'.

AB - Circadian organization can be disrupted by constant light, resulting in behavioral arrhythmicity or 'splitting' of rhythms of activity and rest. By imaging molecular rhythms of individual clock neurons in explanted mouse clock nuclei, we now find that constant light desynchronizes clock neurons but does not compromise their ability to generate circadian rhythms. Cellular synchrony within clock nuclei is disrupted during arrhythmicity, whereas neurons in the left and right clock nuclei cycle in antiphase during 'splitting.'.

UR - http://www.scopus.com/inward/record.url?scp=14544270956&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14544270956&partnerID=8YFLogxK

U2 - 10.1038/nn1395

DO - 10.1038/nn1395

M3 - Article

C2 - 15746913

AN - SCOPUS:14544270956

VL - 8

SP - 267

EP - 269

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 3

ER -