Constitutively active group i mGlu receptors and PKMzeta regulate synaptic transmission in developing perirhinal cortex

Isabella Panaccione, Rachel King, Gemma Molinaro, Barbara Riozzi, Giuseppe Battaglia, Ferdinando Nicoletti, Zafar I. Bashir

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Synaptic transmission is essential for early development of the central nervous system. However, the mechanisms that regulate early synaptic transmission in the cerebral cortex are unclear. PKMζ is a kinase essential for the maintenance of LTP. We show for the first time that inhibition of PKMζ produces a profound depression of basal synaptic transmission in neonatal, but not adult, rat perirhinal cortex. This suggests that synapses in early development are in a constitutive LTP-like state. Furthermore, basal synaptic transmission in immature, but not mature, perirhinal cortex relies on persistent activity of metabotropic glutamate (mGlu) receptor, PI3Kinase and mammalian target of rapamycin (mTOR). Thus early in development, cortical synapses exist in an LTP-like state maintained by tonically active mGlu receptor-, mTOR- and PKMζ- dependent cascades. These results provide new understanding of the molecular mechanisms that control synapses during development and may aid our understanding of developmental disorders such as autism and schizophrenia. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'.

Original languageEnglish (US)
Pages (from-to)143-150
Number of pages8
JournalNeuropharmacology
Volume66
DOIs
StatePublished - Mar 1 2013

Fingerprint

Metabotropic Glutamate Receptors
Synaptic Transmission
Synapses
Sirolimus
Autistic Disorder
Cerebral Cortex
Schizophrenia
Phosphotransferases
Central Nervous System
Maintenance
Perirhinal Cortex

Keywords

  • Cerebral cortex
  • Development
  • Group I mGlu receptor
  • LTP
  • mTOR
  • PKMζ
  • Protein translation

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Constitutively active group i mGlu receptors and PKMzeta regulate synaptic transmission in developing perirhinal cortex. / Panaccione, Isabella; King, Rachel; Molinaro, Gemma; Riozzi, Barbara; Battaglia, Giuseppe; Nicoletti, Ferdinando; Bashir, Zafar I.

In: Neuropharmacology, Vol. 66, 01.03.2013, p. 143-150.

Research output: Contribution to journalArticle

Panaccione, Isabella ; King, Rachel ; Molinaro, Gemma ; Riozzi, Barbara ; Battaglia, Giuseppe ; Nicoletti, Ferdinando ; Bashir, Zafar I. / Constitutively active group i mGlu receptors and PKMzeta regulate synaptic transmission in developing perirhinal cortex. In: Neuropharmacology. 2013 ; Vol. 66. pp. 143-150.
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