Contemporary management of small renal masses

Alessandro Volpe, Jeffrey A Cadeddu, Andrea Cestari, Inderbir S. Gill, Michael A S Jewett, Steven Joniau, Ziya Kirkali, Michael Marberger, Jean Jacques Patard, Michael Staehler, Robert G. Uzzo

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Context: An increasing number of small renal masses (SRMs) with heterogeneous histology and clinical behaviour are being detected with modern radiologic imaging. Although surgical removal is the standard of care for small renal tumours, alternative minimally invasive and conservative treatment options are possible in selected patients with shorter life expectancy. Objective: To systematically review indications, techniques, and outcomes of surgical and conservative treatments of SRMs. Evidence acquisition: A literature search of English-language publications was performed using the Medline database from January 2000 to February 2011 using the terms renal mass and renal carcinoma in conjunction with the evaluated management options. The articles that provided the highest level of evidence were selected with the consensus of all the authors and reviewed. Evidence synthesis: Only one randomised controlled trial comparing the results of elective nephron-sparing surgery and radical nephrectomy for low-stage renal tumours is available. Few comparative studies of different treatment options for SRMs have been published. The assessment of oncologic outcomes is therefore based mainly on observational studies. Most series of nonsurgical therapies have strong selection biases and relatively short follow-up. Treatment selection is based on the clinical and histologic characteristics of SRMs, on patient age and comorbidities, and on personal preferences and experience of the urologist. Conclusions: Partial nephrectomy (PN) is the standard treatment for solitary SRMs whenever it is technically feasible. Laparoscopic PN is an alternative to open PN in experienced hands. The rationale of ablative treatments is to treat incidental cortical SRMs in patients at high surgical risk with potentially reduced morbidity. Active surveillance is considered an appropriate strategy for the elderly or for patients with significant comorbidity who have a shorter life expectancy. Percutaneous biopsies are increasingly being used to establish histology of SRMs and support treatment decisions, especially for patients who are candidates for nonsurgical treatment.

Original languageEnglish (US)
Pages (from-to)501-515
Number of pages15
JournalEuropean Urology
Volume60
Issue number3
DOIs
StatePublished - Sep 2011

Fingerprint

Kidney
Nephrectomy
Life Expectancy
Therapeutics
Comorbidity
Histology
Selection Bias
Nephrons
Standard of Care
Observational Studies
Publications
Neoplasms
Consensus
Language
Randomized Controlled Trials
Outcome Assessment (Health Care)
Databases
Morbidity
Carcinoma
Biopsy

Keywords

  • Carcinoma, renal cell
  • Cryoablation
  • Nephron-sparing surgery
  • Partial nephrectomy
  • Renal mass
  • Renal tumour biopsy
  • Surveillance
  • Thermal ablation

ASJC Scopus subject areas

  • Urology

Cite this

Volpe, A., Cadeddu, J. A., Cestari, A., Gill, I. S., Jewett, M. A. S., Joniau, S., ... Uzzo, R. G. (2011). Contemporary management of small renal masses. European Urology, 60(3), 501-515. https://doi.org/10.1016/j.eururo.2011.05.044

Contemporary management of small renal masses. / Volpe, Alessandro; Cadeddu, Jeffrey A; Cestari, Andrea; Gill, Inderbir S.; Jewett, Michael A S; Joniau, Steven; Kirkali, Ziya; Marberger, Michael; Patard, Jean Jacques; Staehler, Michael; Uzzo, Robert G.

In: European Urology, Vol. 60, No. 3, 09.2011, p. 501-515.

Research output: Contribution to journalArticle

Volpe, A, Cadeddu, JA, Cestari, A, Gill, IS, Jewett, MAS, Joniau, S, Kirkali, Z, Marberger, M, Patard, JJ, Staehler, M & Uzzo, RG 2011, 'Contemporary management of small renal masses', European Urology, vol. 60, no. 3, pp. 501-515. https://doi.org/10.1016/j.eururo.2011.05.044
Volpe A, Cadeddu JA, Cestari A, Gill IS, Jewett MAS, Joniau S et al. Contemporary management of small renal masses. European Urology. 2011 Sep;60(3):501-515. https://doi.org/10.1016/j.eururo.2011.05.044
Volpe, Alessandro ; Cadeddu, Jeffrey A ; Cestari, Andrea ; Gill, Inderbir S. ; Jewett, Michael A S ; Joniau, Steven ; Kirkali, Ziya ; Marberger, Michael ; Patard, Jean Jacques ; Staehler, Michael ; Uzzo, Robert G. / Contemporary management of small renal masses. In: European Urology. 2011 ; Vol. 60, No. 3. pp. 501-515.
@article{4025ccf0cac647989b8f9d17f9b6f77a,
title = "Contemporary management of small renal masses",
abstract = "Context: An increasing number of small renal masses (SRMs) with heterogeneous histology and clinical behaviour are being detected with modern radiologic imaging. Although surgical removal is the standard of care for small renal tumours, alternative minimally invasive and conservative treatment options are possible in selected patients with shorter life expectancy. Objective: To systematically review indications, techniques, and outcomes of surgical and conservative treatments of SRMs. Evidence acquisition: A literature search of English-language publications was performed using the Medline database from January 2000 to February 2011 using the terms renal mass and renal carcinoma in conjunction with the evaluated management options. The articles that provided the highest level of evidence were selected with the consensus of all the authors and reviewed. Evidence synthesis: Only one randomised controlled trial comparing the results of elective nephron-sparing surgery and radical nephrectomy for low-stage renal tumours is available. Few comparative studies of different treatment options for SRMs have been published. The assessment of oncologic outcomes is therefore based mainly on observational studies. Most series of nonsurgical therapies have strong selection biases and relatively short follow-up. Treatment selection is based on the clinical and histologic characteristics of SRMs, on patient age and comorbidities, and on personal preferences and experience of the urologist. Conclusions: Partial nephrectomy (PN) is the standard treatment for solitary SRMs whenever it is technically feasible. Laparoscopic PN is an alternative to open PN in experienced hands. The rationale of ablative treatments is to treat incidental cortical SRMs in patients at high surgical risk with potentially reduced morbidity. Active surveillance is considered an appropriate strategy for the elderly or for patients with significant comorbidity who have a shorter life expectancy. Percutaneous biopsies are increasingly being used to establish histology of SRMs and support treatment decisions, especially for patients who are candidates for nonsurgical treatment.",
keywords = "Carcinoma, renal cell, Cryoablation, Nephron-sparing surgery, Partial nephrectomy, Renal mass, Renal tumour biopsy, Surveillance, Thermal ablation",
author = "Alessandro Volpe and Cadeddu, {Jeffrey A} and Andrea Cestari and Gill, {Inderbir S.} and Jewett, {Michael A S} and Steven Joniau and Ziya Kirkali and Michael Marberger and Patard, {Jean Jacques} and Michael Staehler and Uzzo, {Robert G.}",
year = "2011",
month = "9",
doi = "10.1016/j.eururo.2011.05.044",
language = "English (US)",
volume = "60",
pages = "501--515",
journal = "European Urology",
issn = "0302-2838",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Contemporary management of small renal masses

AU - Volpe, Alessandro

AU - Cadeddu, Jeffrey A

AU - Cestari, Andrea

AU - Gill, Inderbir S.

AU - Jewett, Michael A S

AU - Joniau, Steven

AU - Kirkali, Ziya

AU - Marberger, Michael

AU - Patard, Jean Jacques

AU - Staehler, Michael

AU - Uzzo, Robert G.

PY - 2011/9

Y1 - 2011/9

N2 - Context: An increasing number of small renal masses (SRMs) with heterogeneous histology and clinical behaviour are being detected with modern radiologic imaging. Although surgical removal is the standard of care for small renal tumours, alternative minimally invasive and conservative treatment options are possible in selected patients with shorter life expectancy. Objective: To systematically review indications, techniques, and outcomes of surgical and conservative treatments of SRMs. Evidence acquisition: A literature search of English-language publications was performed using the Medline database from January 2000 to February 2011 using the terms renal mass and renal carcinoma in conjunction with the evaluated management options. The articles that provided the highest level of evidence were selected with the consensus of all the authors and reviewed. Evidence synthesis: Only one randomised controlled trial comparing the results of elective nephron-sparing surgery and radical nephrectomy for low-stage renal tumours is available. Few comparative studies of different treatment options for SRMs have been published. The assessment of oncologic outcomes is therefore based mainly on observational studies. Most series of nonsurgical therapies have strong selection biases and relatively short follow-up. Treatment selection is based on the clinical and histologic characteristics of SRMs, on patient age and comorbidities, and on personal preferences and experience of the urologist. Conclusions: Partial nephrectomy (PN) is the standard treatment for solitary SRMs whenever it is technically feasible. Laparoscopic PN is an alternative to open PN in experienced hands. The rationale of ablative treatments is to treat incidental cortical SRMs in patients at high surgical risk with potentially reduced morbidity. Active surveillance is considered an appropriate strategy for the elderly or for patients with significant comorbidity who have a shorter life expectancy. Percutaneous biopsies are increasingly being used to establish histology of SRMs and support treatment decisions, especially for patients who are candidates for nonsurgical treatment.

AB - Context: An increasing number of small renal masses (SRMs) with heterogeneous histology and clinical behaviour are being detected with modern radiologic imaging. Although surgical removal is the standard of care for small renal tumours, alternative minimally invasive and conservative treatment options are possible in selected patients with shorter life expectancy. Objective: To systematically review indications, techniques, and outcomes of surgical and conservative treatments of SRMs. Evidence acquisition: A literature search of English-language publications was performed using the Medline database from January 2000 to February 2011 using the terms renal mass and renal carcinoma in conjunction with the evaluated management options. The articles that provided the highest level of evidence were selected with the consensus of all the authors and reviewed. Evidence synthesis: Only one randomised controlled trial comparing the results of elective nephron-sparing surgery and radical nephrectomy for low-stage renal tumours is available. Few comparative studies of different treatment options for SRMs have been published. The assessment of oncologic outcomes is therefore based mainly on observational studies. Most series of nonsurgical therapies have strong selection biases and relatively short follow-up. Treatment selection is based on the clinical and histologic characteristics of SRMs, on patient age and comorbidities, and on personal preferences and experience of the urologist. Conclusions: Partial nephrectomy (PN) is the standard treatment for solitary SRMs whenever it is technically feasible. Laparoscopic PN is an alternative to open PN in experienced hands. The rationale of ablative treatments is to treat incidental cortical SRMs in patients at high surgical risk with potentially reduced morbidity. Active surveillance is considered an appropriate strategy for the elderly or for patients with significant comorbidity who have a shorter life expectancy. Percutaneous biopsies are increasingly being used to establish histology of SRMs and support treatment decisions, especially for patients who are candidates for nonsurgical treatment.

KW - Carcinoma, renal cell

KW - Cryoablation

KW - Nephron-sparing surgery

KW - Partial nephrectomy

KW - Renal mass

KW - Renal tumour biopsy

KW - Surveillance

KW - Thermal ablation

UR - http://www.scopus.com/inward/record.url?scp=79960983717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960983717&partnerID=8YFLogxK

U2 - 10.1016/j.eururo.2011.05.044

DO - 10.1016/j.eururo.2011.05.044

M3 - Article

C2 - 21664040

AN - SCOPUS:79960983717

VL - 60

SP - 501

EP - 515

JO - European Urology

JF - European Urology

SN - 0302-2838

IS - 3

ER -