TY - JOUR
T1 - Contemporary mouse models in glioma research
AU - Hicks, William H.
AU - Bird, Cylaina E.
AU - Traylor, Jeffrey I.
AU - Shi, Diana D.
AU - El Ahmadieh, Tarek Y.
AU - Richardson, Timothy E.
AU - McBrayer, Samuel K.
AU - Abdullah, Kalil G.
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/3
Y1 - 2021/3
N2 - Despite advances in understanding of the molecular pathogenesis of glioma, outcomes remain dismal. Developing successful treatments for glioma requires faithful in vivo disease modeling and rigorous preclinical testing. Murine models, including xenograft, syngeneic, and genetically engineered models, are used to study glioma-genesis, identify methods of tumor progression, and test novel treatment strategies. Since the discovery of highly recurrent isocitrate dehydrogenase (IDH) mutations in lower-grade gliomas, there is increasing emphasis on effective modeling of IDH mutant brain tumors. Improvements in preclinical models that capture the phenotypic and molecular heterogeneity of gliomas are critical for the development of effective new therapies. Herein, we explore the current status, advancements, and challenges with contemporary murine glioma models.
AB - Despite advances in understanding of the molecular pathogenesis of glioma, outcomes remain dismal. Developing successful treatments for glioma requires faithful in vivo disease modeling and rigorous preclinical testing. Murine models, including xenograft, syngeneic, and genetically engineered models, are used to study glioma-genesis, identify methods of tumor progression, and test novel treatment strategies. Since the discovery of highly recurrent isocitrate dehydrogenase (IDH) mutations in lower-grade gliomas, there is increasing emphasis on effective modeling of IDH mutant brain tumors. Improvements in preclinical models that capture the phenotypic and molecular heterogeneity of gliomas are critical for the development of effective new therapies. Herein, we explore the current status, advancements, and challenges with contemporary murine glioma models.
KW - Genetically engineered mouse models (GEMM)
KW - Glioma
KW - Isocitrate dehydrogenase (IDH)
KW - Mouse model
KW - Patient-derived xenograft (PDX)
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U2 - 10.3390/cells10030712
DO - 10.3390/cells10030712
M3 - Review article
C2 - 33806933
AN - SCOPUS:85103863239
SN - 2073-4409
VL - 10
JO - Cells
JF - Cells
IS - 3
M1 - 712
ER -