Contemporary paradigms for cholinergic ligand design guided by biological structure

Palmer Taylor, Scott B. Hansen, Todd T. Talley, Ryan E. Hibbs, Zoran Radić

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The identification of the various nicotinic receptor subtypes, when coupled with the recent development of three-dimensional structures of surrogate extracellular receptor domains, offers new opportunities to design nicotinic ligands. Conformation and fluctuations in receptor structure are critical to ligand selectivity, and we present here how a flexible receptor template can be used in the development of selective ligands affecting cholinergic neurotransmission.

Original languageEnglish (US)
Pages (from-to)1875-1877
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number8
DOIs
StatePublished - Apr 19 2004

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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