Contemporary paradigms for cholinergic ligand design guided by biological structure

Palmer Taylor; Scott B. Hansen; Todd T. Talley; Ryan E. Hibbs; Zoran Radić

doi:10.1016/j.bmcl.2003.10.072

Contemporary paradigms for cholinergic ligand design guided by biological structure

Palmer Taylor, Scott B. Hansen, Todd T. Talley, Ryan E. Hibbs, Zoran Radić

Research output: Contribution to journal › Article › peer-review

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Abstract

The identification of the various nicotinic receptor subtypes, when coupled with the recent development of three-dimensional structures of surrogate extracellular receptor domains, offers new opportunities to design nicotinic ligands. Conformation and fluctuations in receptor structure are critical to ligand selectivity, and we present here how a flexible receptor template can be used in the development of selective ligands affecting cholinergic neurotransmission.

Original language	English (US)
Pages (from-to)	1875-1877
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	8
DOIs	https://doi.org/10.1016/j.bmcl.2003.10.072
State	Published - Apr 19 2004

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2003.10.072

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abstract = "The identification of the various nicotinic receptor subtypes, when coupled with the recent development of three-dimensional structures of surrogate extracellular receptor domains, offers new opportunities to design nicotinic ligands. Conformation and fluctuations in receptor structure are critical to ligand selectivity, and we present here how a flexible receptor template can be used in the development of selective ligands affecting cholinergic neurotransmission.",

author = "Palmer Taylor and Hansen, {Scott B.} and Talley, {Todd T.} and Hibbs, {Ryan E.} and Zoran Radi{\'c}",

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AU - Radić, Zoran

PY - 2004/4/19

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AB - The identification of the various nicotinic receptor subtypes, when coupled with the recent development of three-dimensional structures of surrogate extracellular receptor domains, offers new opportunities to design nicotinic ligands. Conformation and fluctuations in receptor structure are critical to ligand selectivity, and we present here how a flexible receptor template can be used in the development of selective ligands affecting cholinergic neurotransmission.

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Contemporary paradigms for cholinergic ligand design guided by biological structure

Abstract

ASJC Scopus subject areas

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