Contemporary Revascularization Strategies and Outcomes Among Patients With Diabetes With Critical Limb Ischemia: Insights From the National Inpatient Sample

Ayman Elbadawi, Islam Y. Elgendy, Marwan Saad, Mohammed Elzeneini, Michael Megaly, Mohamed Omer, Subhash Banerjee, Douglas E. Drachman, Herbert D. Aronow

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objectives: The purpose of this study was to evaluate temporal trends in the frequency of revascularization and associated outcomes in patients with diabetes mellitus and critical limb ischemia (CLI). Background: Little is known about outcomes following revascularization for CLI in patients with diabetes mellitus. Methods: Temporal trends in hospitalization for CLI among patients with diabetes were determined using the 2002–2015 National Inpatient Sample database. Propensity score matching was used to compare patients who underwent revascularization with those who did not and, separately, to compare those who underwent endovascular versus surgical revascularization. The main study outcome was in-hospital mortality. Results: The analysis included 1,222,324 hospitalizations. The number of hospitalizations for CLI among patients with diabetes increased over time (ptrend < 0.001). There was an increase in the use of lower extremity revascularization, paralleled by a decline in in-hospital mortality during the study period. In the matched cohort, patients who were revascularized had lower in-hospital mortality (odds ratio [OR]: 0.68; 95% confidence interval [CI]: 0.63 to 0.72) and major amputation (OR: 0.25; 95% CI: 0.24 to 0.27) compared with those who were treated medically. Compared with endovascular revascularization, those who underwent surgical revascularization had higher rates of in-hospital mortality (OR: 1.18; 95% CI: 1.04 to 1.35) but lower rates of major amputation (OR: 0.75; 95% CI: 0.70 to 0.81). Major bleeding, blood transfusion, post-operative infection, respiratory complications, discharges to nursing facility, and longer length of hospital stay were also more common among those who underwent surgery. Conclusions: In this national analysis of patients with DM and CLI, we demonstrated an increase in hospitalization for CLI among patients with diabetes in the United States. Although in-hospital mortality decreased over time regardless of the treatment strategy used, this outcome occurred less frequently among those who underwent revascularization than not. Compared with surgical revascularization, endovascular revascularization was associated with lower in-hospital mortality but higher rates of major amputation.

Original languageEnglish (US)
Pages (from-to)664-674
Number of pages11
JournalJACC: Cardiovascular Interventions
Volume14
Issue number6
DOIs
StatePublished - Mar 22 2021

Keywords

  • critical limb ischemia
  • diabetes mellitus
  • endovascular revascularization
  • surgical revascularization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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