Continuous Arterial Spin Labeled Perfusion Magnetic Resonance Imaging in Patients before and after Carotid Endarterectomy

Beau M. Ances, Michael L. McGarvey, John M. Abrahams, Joseph A Maldjian, David C. Alsop, Eric L. Zager, John A. Detre

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Continuous arterial spin labeling perfusion magnetic resonance imaging (CASL-pMRI) uses magnetically labeled arterial blood water as a tracer to obtain quantifiable measurements of cerebral blood flow (CBF) (mL/100 g -1/min-1). CASL-pMRI was used to assess CBF changes in major vascular distributions in patients (n = 10) prior to and 3 months after carotid endarterectomy (CEA). No significant change in the global baseline CBF before and after CEA was observed in the group as a whole (P = .81). In patients with reduced CBF prior to CEA (< 50 ml/100 g/min), a significant increase in global CBF following CEA was observed. An inverse relationship existed between percent change in CBF after CEA versus baseline CBF within the anterior circulation (r = -.78, P < .05) but not in the posterior distribution (r = .25, P = .63). CASL-pMRI may provide a convenient, inexpensive, noninvasive method for identifying CEA patients at risk for hyperperfusion following carotid revascularization.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalJournal of Neuroimaging
Volume14
Issue number2
DOIs
StatePublished - Apr 1 2004

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Cerebrovascular Circulation
Carotid Endarterectomy
Magnetic Resonance Angiography
Blood Vessels

Keywords

  • Carotid endarterectomy
  • Carotid stenosis
  • Cerebral blood flow
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Cite this

Continuous Arterial Spin Labeled Perfusion Magnetic Resonance Imaging in Patients before and after Carotid Endarterectomy. / Ances, Beau M.; McGarvey, Michael L.; Abrahams, John M.; Maldjian, Joseph A; Alsop, David C.; Zager, Eric L.; Detre, John A.

In: Journal of Neuroimaging, Vol. 14, No. 2, 01.04.2004, p. 133-138.

Research output: Contribution to journalArticle

Ances, Beau M. ; McGarvey, Michael L. ; Abrahams, John M. ; Maldjian, Joseph A ; Alsop, David C. ; Zager, Eric L. ; Detre, John A. / Continuous Arterial Spin Labeled Perfusion Magnetic Resonance Imaging in Patients before and after Carotid Endarterectomy. In: Journal of Neuroimaging. 2004 ; Vol. 14, No. 2. pp. 133-138.
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