Contractile properties of the denervated external anal sphincter

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Abstract

Objective: The purpose of this study was to evaluate the effect of denervation on contractile properties of the external anal sphincter (EAS) of the female rat. Study Design: Sham operation, pudendal nerve transection, pelvic neurectomy, or combined pudendal nerve transection/pelvic neurectomy was performed in young female rats. Contractile function of the EAS was determined after 2 weeks. Results: Maximal force-generating capacity of the EAS was not impaired by bilateral pudendal denervation or pelvic neurectomy. Twitch tension, however, was decreased, and fatigability increased after pelvic neurectomy. Combined bilateral pudendal nerve-transection plus pelvic neurectomy resulted in compromised force-generating capacity, decreased twitch tension, and increased fatigability of the anal sphincter. Conclusion: Subtle changes in EAS function are detectable after pelvic neurectomy, but not pudendal denervation. In contrast, combination pudendal and pelvic neurectomy resulted in severe compromise of EAS function. These data suggest that EAS function is relatively preserved unless injury occurs to > 1 source of innervation.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume200
Issue number6
DOIs
StatePublished - Jun 2009

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Anal Canal
Pudendal Nerve
Denervation
Wounds and Injuries

Keywords

  • anal incontinence
  • denervation
  • pelvic neurectomy
  • pudendal nerve
  • rat

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

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title = "Contractile properties of the denervated external anal sphincter",
abstract = "Objective: The purpose of this study was to evaluate the effect of denervation on contractile properties of the external anal sphincter (EAS) of the female rat. Study Design: Sham operation, pudendal nerve transection, pelvic neurectomy, or combined pudendal nerve transection/pelvic neurectomy was performed in young female rats. Contractile function of the EAS was determined after 2 weeks. Results: Maximal force-generating capacity of the EAS was not impaired by bilateral pudendal denervation or pelvic neurectomy. Twitch tension, however, was decreased, and fatigability increased after pelvic neurectomy. Combined bilateral pudendal nerve-transection plus pelvic neurectomy resulted in compromised force-generating capacity, decreased twitch tension, and increased fatigability of the anal sphincter. Conclusion: Subtle changes in EAS function are detectable after pelvic neurectomy, but not pudendal denervation. In contrast, combination pudendal and pelvic neurectomy resulted in severe compromise of EAS function. These data suggest that EAS function is relatively preserved unless injury occurs to > 1 source of innervation.",
keywords = "anal incontinence, denervation, pelvic neurectomy, pudendal nerve, rat",
author = "Wai, {Clifford Y.} and Word, {R. Ann}",
year = "2009",
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N2 - Objective: The purpose of this study was to evaluate the effect of denervation on contractile properties of the external anal sphincter (EAS) of the female rat. Study Design: Sham operation, pudendal nerve transection, pelvic neurectomy, or combined pudendal nerve transection/pelvic neurectomy was performed in young female rats. Contractile function of the EAS was determined after 2 weeks. Results: Maximal force-generating capacity of the EAS was not impaired by bilateral pudendal denervation or pelvic neurectomy. Twitch tension, however, was decreased, and fatigability increased after pelvic neurectomy. Combined bilateral pudendal nerve-transection plus pelvic neurectomy resulted in compromised force-generating capacity, decreased twitch tension, and increased fatigability of the anal sphincter. Conclusion: Subtle changes in EAS function are detectable after pelvic neurectomy, but not pudendal denervation. In contrast, combination pudendal and pelvic neurectomy resulted in severe compromise of EAS function. These data suggest that EAS function is relatively preserved unless injury occurs to > 1 source of innervation.

AB - Objective: The purpose of this study was to evaluate the effect of denervation on contractile properties of the external anal sphincter (EAS) of the female rat. Study Design: Sham operation, pudendal nerve transection, pelvic neurectomy, or combined pudendal nerve transection/pelvic neurectomy was performed in young female rats. Contractile function of the EAS was determined after 2 weeks. Results: Maximal force-generating capacity of the EAS was not impaired by bilateral pudendal denervation or pelvic neurectomy. Twitch tension, however, was decreased, and fatigability increased after pelvic neurectomy. Combined bilateral pudendal nerve-transection plus pelvic neurectomy resulted in compromised force-generating capacity, decreased twitch tension, and increased fatigability of the anal sphincter. Conclusion: Subtle changes in EAS function are detectable after pelvic neurectomy, but not pudendal denervation. In contrast, combination pudendal and pelvic neurectomy resulted in severe compromise of EAS function. These data suggest that EAS function is relatively preserved unless injury occurs to > 1 source of innervation.

KW - anal incontinence

KW - denervation

KW - pelvic neurectomy

KW - pudendal nerve

KW - rat

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