Contralateral functional reorganization of the speech supplementary motor area following neurosurgical tumor resection

Srinivas Chivukula, Brian K. Pikul, Keith L. Black, Nader Pouratian, Susan Y. Bookheimer

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated plasticity in speech supplemental motor area (SMA) tissue in two patients using functional magnetic resonance imaging (fMRI), following resection of tumors in or associated with the dominant hemisphere speech SMA. Patient A underwent resection of a anaplastic astrocytoma NOS associated with the left speech SMA, experienced SMA syndrome related mutism postoperatively, but experienced full recovery 14 months later. FMRI performed 32 months after surgery demonstrated a migration of speech SMA to homologous contralateral hemispheric regional tissue. Patient B underwent resection of a oligodendroglioma NOS in the left speech SMA, and postoperatively experienced speech hesitancy, latency and poor fluency, which gradually resolved over 18 months. FMRI performed at 64 months after surgery showed a reorganization of speech SMA to the contralateral hemisphere. These data support the hypothesis of dynamic, time based plasticity in speech SMA tissue, and may represent a noninvasive neural marker for SMA syndrome recovery.

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalBrain and language
Volume183
DOIs
StatePublished - Aug 2018
Externally publishedYes

Keywords

  • Contralateral
  • Reorganization
  • SMA
  • Speech SMA
  • Supplementary motor area

ASJC Scopus subject areas

  • Language and Linguistics
  • Experimental and Cognitive Psychology
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

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