@article{9249fa173c2544a6a12e8413b32d7486,
title = "Contrast-enhanced magnetic resonance imaging for the detection of ruptured coronary plaques in patients with acute myocardial infarction",
abstract = "Purpose: X-ray coronary angiography (XCA) is the current gold standard for the assessment of lumen encroaching coronary stenosis but XCA does not allow for early detection of rupture-prone vulnerable plaques, which are thought to be the precursor lesions of most acute myocardial infarctions (AMI) and sudden death. The aim of this study was to investigate the potential of delayed contrast-enhanced magnetic resonance coronary vessel wall imaging (CE-MRCVI) for the detection of culprit lesions in the coronary arteries. Methods: 16 patients (13 male, age 61.9±8.6 years) presenting with sub-acute MI underwent CE-MRCVI within 24-72h prior to invasive XCA. CE-MRCVI was performed using a T1-weighted 3D gradient echo inversion recovery sequence (3D IR TFE) 40±4 minutes following the administration of 0.2 mmol/kg gadolinium-diethylenetriamine-pentaacetic acid (DTPA) on a 3T MRI scanner equipped with a 32-channel cardiac coil. Results: 14 patients were found to have culprit lesions (7x LAD, 1xLCX, 6xRCA) as identified by XCA. Quantitative CE-MRCVI correctly identified the culprit lesion location with a sensitivity of 79% and excluded culprit lesion formation with a specificity of 99%. The contrast to noise ratio (CNR) of culprit lesions (9.7±4.1) significantly exceeded CNR values of segments without culprit lesions (2.9±1.9, p<0.001). Conclusion: CE-MRCVI allows the selective visualization of culprit lesions in patients immediately after myocardial infarction (MI). The pronounced contrast uptake in ruptured plaques may represent a surrogate biomarker of plaque activity and/or vulnerability.",
author = "Jansen, {Christian H.P.} and Divaka Perera and Wiethoff, {Andrea J.} and Alkystis Phinikaridou and Razavi, {Reza M.} and Aldo Rinaldi and Marber, {Mike S.} and Greil, {Gerald F.} and Eike Nagel and David Maintz and Simon Redwood and Botnar, {Rene M.} and Makowski, {Marcus R.}",
note = "Funding Information: The authors acknowledge financial support from the British Heart Foundation (https://www.bhf.org.uk/) (PG/10/044/28343) and the BHF Centre of Excellence (https://www.bhf.org.uk/research/where-we-fund-research/centres-of-research-excellence) (RE/08/03). The Division of Imaging Sciences receives also support from the Centre of Excellence in Medical Engineering (funded by the Welcome Trust and EPSRC; grant number WT 088641/Z/09/Z) (https://www.epsrc.ac.uk/) and the Department of Health through the National Institute for Health Research (NIHR) Biomedical Research Centre award to Guy{\textquoteright}s and St Thomas{\textquoteright} NHS Foundation Trust in partnership with King{\textquoteright}s College London, and by the NIHR Healthcare Technology Co-operative for Cardiovascular Disease at Guy{\textquoteright}s and St Thomas{\textquoteright} NHS Foundation Trust. The views expressed are those of the author (s) and not necessarily those of the NHS, the NIHR or the Department of Health. The author MRM is grateful for the financial support from the Deutsche Forschungsgemeinschaft (http://www.dfg.de/) (DFG, 594331/41/91). The authors acknowledge financial support from the British Heart Foundation (https://www.bhf.org.uk/) (PG/10/044/28343) and the BHF Centre of Excellence (https://www.bhf.org.uk/research/where-we-fund-research/centres-of-research-excellence) (RE/08/03). The Division of Imaging Sciences receives also support from the Centre of Excellence in Medical Engineering (funded by the Welcome Trust and EPSRC; grant number WT 088641/Z/09/Z) (https://www.epsrc.ac.uk/) and the Department of Health through the National Institute for Health Research (NIHR) Biomedical Research Centre award to Guy{\textquoteright}s and St Thomas{\textquoteright} NHS Foundation Trust in partnership with King{\textquoteright}s College London, and by the NIHR Healthcare Technology Co- operative for Cardiovascular Disease at Guy{\textquoteright}s and St Thomas{\textquoteright} NHS Foundation Trust. The views expressed are those of the author (s) and not necessarily those of the NHS, the NIHR or the Department of Health. The author MRM is grateful for the financial support from the Deutsche Forschungsgemeinschaft (http://www.dfg.de/) (DFG, 594331/41/91). The author AW is affiliated to Philips Healthcare. This does not alter our adherence to PLOS ONE policies on sharing data and materials. Publisher Copyright: {\textcopyright} 2017 Jansen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2017",
month = nov,
doi = "10.1371/journal.pone.0188292",
language = "English (US)",
volume = "12",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",
}