Contrast-enhanced ultrasound of the abdominal aorta – current status and future perspectives

Xin Li, Daniel Staub, Vasileios Rafailidis, Mohammed Al-Natour, Sanjeeva P Kalva, Sasan Partovi

Research output: Contribution to journalReview article

Abstract

Ultrasound has been established as an important diagnostic tool in assessing vascular abnormalities. Standard B-mode and Doppler techniques have inherent limitations with regards to detection of slow flow and small vasculature. Contrast-enhanced ultrasound (CEUS) is a complementary tool and is useful in assessing both the macro-and microvascular anatomy of the aorta. CEUS can also provide valuable physiological information in real-time scanning sessions due to the physical and safety profiles of the administered microbubbles. From a macrovascular perspective, CEUS has been used to characterize aortic aneurysm rupture, dissection and endoleaks post-EVAR repair. With regard to microvasculature CEUS enables imaging of adventitial vasa vasorum thereby assessing aortic inflammation processes, such as monitoring treatment response in chronic periaortitis. CEUS may have additional clinical utility since adventitial vasa vasorum has important implications in the pathogenesis of aortic diseases. In recent years, there have been an increasing number of studies comparing CEUS to cross-sectional imaging for aortic applications. For endoleak surveillance CEUS has been shown to be equal or in certain cases superior in comparison to CT angiography. The recent advancement of CEUS software along with the ongoing development of drug-eluting contrast microbubbles has allowed improved targeted detection and real-time ultrasound guided therapy for aortic vasa vasorum inflammation and neovascularization in animal models. Therefore, CEUS is uniquely suited to comprehensively assess and potentially treat aortic vascular diseases in the future.

Original languageEnglish (US)
Pages (from-to)115-125
Number of pages11
JournalVasa - European Journal of Vascular Medicine
Volume48
Issue number2
DOIs
StatePublished - Jan 1 2019

Fingerprint

Vasa Vasorum
Abdominal Aorta
Endoleak
Microbubbles
Adventitia
Aortic Diseases
Retroperitoneal Fibrosis
Inflammation
Aortic Rupture
Aortic Aneurysm
Microvessels
Vascular Diseases
Blood Vessels
Aorta
Dissection
Ultrasonography
Anatomy
Software
Animal Models
Safety

Keywords

  • Aorta
  • CEUS
  • EVAR
  • Periaortitis
  • Targeted ultrasound contrast agent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Contrast-enhanced ultrasound of the abdominal aorta – current status and future perspectives. / Li, Xin; Staub, Daniel; Rafailidis, Vasileios; Al-Natour, Mohammed; Kalva, Sanjeeva P; Partovi, Sasan.

In: Vasa - European Journal of Vascular Medicine, Vol. 48, No. 2, 01.01.2019, p. 115-125.

Research output: Contribution to journalReview article

Li, Xin ; Staub, Daniel ; Rafailidis, Vasileios ; Al-Natour, Mohammed ; Kalva, Sanjeeva P ; Partovi, Sasan. / Contrast-enhanced ultrasound of the abdominal aorta – current status and future perspectives. In: Vasa - European Journal of Vascular Medicine. 2019 ; Vol. 48, No. 2. pp. 115-125.
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