Contrasting hemodynamic responses in severe heart failure: Comparison of captopril and other vasodilator drugs

Milton Packer, Norma Medina, Madeline Yushak

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Four studies were conducted in 36 patients with severe chronic heart failure to compare the central hemodynamic effects of captopril (CPT) to other vasodilator agents. While CPT produced less marked increases in cardiac output than did hydralazine (n = 14), nitroprusside (n = 15), or prazosin (n = 7), it produced decreases in left ventricular filling pressures similar to nitroprusside and prazosin but more than hydralazine. CPT and isosorbide dinitrate (n = 11) produced similar decreases in systemic vascular resistance and left ventricular filling pressure. However, cardiac output increased less with CPT than with nitrates, because heart rate slowed during CPT therapy. In addition, mean right atrial pressure decreased less with CPT than with nitrates, because CPT had minimal effects on limb venous capacitance and pulmonary arteriolar resistance. Alterations in left ventricular pressure-volume relationships likely contributed to the marked decreases in left ventricular filling pressures seen with CPT. In conclusion, the central hemodynamic effects of CPT differ significantly from other vasodilator drugs used in the treatment of heart failure patients. These effects cannot be characterized simply in terms of "balanced" peripheral arterial and venous vasodilation; CPT exerts highly complex effects on peripheral vessels as well as having actions independent of its peripheral vasodilator effects.

Original languageEnglish (US)
Pages (from-to)1215-1223
Number of pages9
JournalAmerican Heart Journal
Volume104
Issue number5 PART 2
DOIs
StatePublished - 1982

Fingerprint

Captopril
Vasodilator Agents
Heart Failure
Hemodynamics
Ventricular Pressure
Hydralazine
Prazosin
Nitroprusside
Cardiac Output
Nitrates
Isosorbide Dinitrate
Atrial Pressure
Treatment Failure
Vasodilation
Vascular Resistance
Extremities
Heart Rate
Lung

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Contrasting hemodynamic responses in severe heart failure : Comparison of captopril and other vasodilator drugs. / Packer, Milton; Medina, Norma; Yushak, Madeline.

In: American Heart Journal, Vol. 104, No. 5 PART 2, 1982, p. 1215-1223.

Research output: Contribution to journalArticle

Packer, Milton ; Medina, Norma ; Yushak, Madeline. / Contrasting hemodynamic responses in severe heart failure : Comparison of captopril and other vasodilator drugs. In: American Heart Journal. 1982 ; Vol. 104, No. 5 PART 2. pp. 1215-1223.
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