Contribution of dietary advanced glycation end products (AGE) to circulating AGE: Role of dietary fat

Kathleen E. Davis, Chandan Prasad, Parakat Vijayagopal, Shanil Juma, Beverley Adams-Huet, Victorine Imrhan

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The purpose of this pilot study was to determine whether macronutrient content (low-fat v. high-fat diet) influences an indicator of advanced glycation end products (AGE), N I carboxymethyl-lysine (CML), in the context of a 1-d, high-AGE diet. The effect of the diets on inflammatory markers was also assessed. A total of nineteen overweight and obese adults (nine men and ten women) without known disease were recruited to participate in a crossover challenge of a high-fat, high-AGE (HFHA) and low-fat, high-AGE (LFHA) diet. In each phase patients had fasting blood drawn, followed by consumption of a high-fat or low-fat breakfast test meal, then three postprandial blood draws at 1, 2 and 3 h after consuming the test meal. After consuming high-AGE meals for the remainder of the day, participants returned the next day for a follow-up analysis. A different pattern in the 3-h post-meal CML and soluble receptor for AGE response to the two diets was observed (P=0·01 and 0·05, respectively). No change in serum CML was observed following consumption of a LFHA breakfast (535 (25th-75th percentile 451-790) to 495 (25th-75th percentile 391-682) ng/ml; P=0·36), whereas a rise in CML occurred after the HFHA breakfast (463 (25th-75th percentile 428-664) to 578 (25th-75th percentile 474-865) ng/ml; P=0·05). High sensitivity C-reactive protein and high molecular weight adiponectin were not affected by either diet. These findings suggest that dietary CML may not be as important in influencing serum CML as other dietary factors. In addition, acute exposure to dietary CML may not influence inflammation in adults without diabetes or kidney disease. This is contrary to previous findings.

Original languageEnglish (US)
Pages (from-to)1797-1806
Number of pages10
JournalBritish Journal of Nutrition
Volume114
Issue number11
DOIs
StatePublished - Sep 22 2015

Fingerprint

Advanced Glycosylation End Products
Dietary Fats
Fats
Breakfast
Meals
Diet
Adiponectin
Kidney Diseases
High Fat Diet
N(6)-carboxymethyllysine
Serum
C-Reactive Protein
Fasting
Molecular Weight
Inflammation

Keywords

  • Advanced glycation end products
  • Glycotoxins
  • High-fat diet
  • Inflammation
  • Low-fat diet
  • Maillard reaction products
  • Obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Contribution of dietary advanced glycation end products (AGE) to circulating AGE : Role of dietary fat. / Davis, Kathleen E.; Prasad, Chandan; Vijayagopal, Parakat; Juma, Shanil; Adams-Huet, Beverley; Imrhan, Victorine.

In: British Journal of Nutrition, Vol. 114, No. 11, 22.09.2015, p. 1797-1806.

Research output: Contribution to journalArticle

Davis, Kathleen E. ; Prasad, Chandan ; Vijayagopal, Parakat ; Juma, Shanil ; Adams-Huet, Beverley ; Imrhan, Victorine. / Contribution of dietary advanced glycation end products (AGE) to circulating AGE : Role of dietary fat. In: British Journal of Nutrition. 2015 ; Vol. 114, No. 11. pp. 1797-1806.
@article{38b491908005439289cc91c3047aab80,
title = "Contribution of dietary advanced glycation end products (AGE) to circulating AGE: Role of dietary fat",
abstract = "The purpose of this pilot study was to determine whether macronutrient content (low-fat v. high-fat diet) influences an indicator of advanced glycation end products (AGE), N I carboxymethyl-lysine (CML), in the context of a 1-d, high-AGE diet. The effect of the diets on inflammatory markers was also assessed. A total of nineteen overweight and obese adults (nine men and ten women) without known disease were recruited to participate in a crossover challenge of a high-fat, high-AGE (HFHA) and low-fat, high-AGE (LFHA) diet. In each phase patients had fasting blood drawn, followed by consumption of a high-fat or low-fat breakfast test meal, then three postprandial blood draws at 1, 2 and 3 h after consuming the test meal. After consuming high-AGE meals for the remainder of the day, participants returned the next day for a follow-up analysis. A different pattern in the 3-h post-meal CML and soluble receptor for AGE response to the two diets was observed (P=0·01 and 0·05, respectively). No change in serum CML was observed following consumption of a LFHA breakfast (535 (25th-75th percentile 451-790) to 495 (25th-75th percentile 391-682) ng/ml; P=0·36), whereas a rise in CML occurred after the HFHA breakfast (463 (25th-75th percentile 428-664) to 578 (25th-75th percentile 474-865) ng/ml; P=0·05). High sensitivity C-reactive protein and high molecular weight adiponectin were not affected by either diet. These findings suggest that dietary CML may not be as important in influencing serum CML as other dietary factors. In addition, acute exposure to dietary CML may not influence inflammation in adults without diabetes or kidney disease. This is contrary to previous findings.",
keywords = "Advanced glycation end products, Glycotoxins, High-fat diet, Inflammation, Low-fat diet, Maillard reaction products, Obesity",
author = "Davis, {Kathleen E.} and Chandan Prasad and Parakat Vijayagopal and Shanil Juma and Beverley Adams-Huet and Victorine Imrhan",
year = "2015",
month = "9",
day = "22",
doi = "10.1017/S0007114515003487",
language = "English (US)",
volume = "114",
pages = "1797--1806",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "11",

}

TY - JOUR

T1 - Contribution of dietary advanced glycation end products (AGE) to circulating AGE

T2 - Role of dietary fat

AU - Davis, Kathleen E.

AU - Prasad, Chandan

AU - Vijayagopal, Parakat

AU - Juma, Shanil

AU - Adams-Huet, Beverley

AU - Imrhan, Victorine

PY - 2015/9/22

Y1 - 2015/9/22

N2 - The purpose of this pilot study was to determine whether macronutrient content (low-fat v. high-fat diet) influences an indicator of advanced glycation end products (AGE), N I carboxymethyl-lysine (CML), in the context of a 1-d, high-AGE diet. The effect of the diets on inflammatory markers was also assessed. A total of nineteen overweight and obese adults (nine men and ten women) without known disease were recruited to participate in a crossover challenge of a high-fat, high-AGE (HFHA) and low-fat, high-AGE (LFHA) diet. In each phase patients had fasting blood drawn, followed by consumption of a high-fat or low-fat breakfast test meal, then three postprandial blood draws at 1, 2 and 3 h after consuming the test meal. After consuming high-AGE meals for the remainder of the day, participants returned the next day for a follow-up analysis. A different pattern in the 3-h post-meal CML and soluble receptor for AGE response to the two diets was observed (P=0·01 and 0·05, respectively). No change in serum CML was observed following consumption of a LFHA breakfast (535 (25th-75th percentile 451-790) to 495 (25th-75th percentile 391-682) ng/ml; P=0·36), whereas a rise in CML occurred after the HFHA breakfast (463 (25th-75th percentile 428-664) to 578 (25th-75th percentile 474-865) ng/ml; P=0·05). High sensitivity C-reactive protein and high molecular weight adiponectin were not affected by either diet. These findings suggest that dietary CML may not be as important in influencing serum CML as other dietary factors. In addition, acute exposure to dietary CML may not influence inflammation in adults without diabetes or kidney disease. This is contrary to previous findings.

AB - The purpose of this pilot study was to determine whether macronutrient content (low-fat v. high-fat diet) influences an indicator of advanced glycation end products (AGE), N I carboxymethyl-lysine (CML), in the context of a 1-d, high-AGE diet. The effect of the diets on inflammatory markers was also assessed. A total of nineteen overweight and obese adults (nine men and ten women) without known disease were recruited to participate in a crossover challenge of a high-fat, high-AGE (HFHA) and low-fat, high-AGE (LFHA) diet. In each phase patients had fasting blood drawn, followed by consumption of a high-fat or low-fat breakfast test meal, then three postprandial blood draws at 1, 2 and 3 h after consuming the test meal. After consuming high-AGE meals for the remainder of the day, participants returned the next day for a follow-up analysis. A different pattern in the 3-h post-meal CML and soluble receptor for AGE response to the two diets was observed (P=0·01 and 0·05, respectively). No change in serum CML was observed following consumption of a LFHA breakfast (535 (25th-75th percentile 451-790) to 495 (25th-75th percentile 391-682) ng/ml; P=0·36), whereas a rise in CML occurred after the HFHA breakfast (463 (25th-75th percentile 428-664) to 578 (25th-75th percentile 474-865) ng/ml; P=0·05). High sensitivity C-reactive protein and high molecular weight adiponectin were not affected by either diet. These findings suggest that dietary CML may not be as important in influencing serum CML as other dietary factors. In addition, acute exposure to dietary CML may not influence inflammation in adults without diabetes or kidney disease. This is contrary to previous findings.

KW - Advanced glycation end products

KW - Glycotoxins

KW - High-fat diet

KW - Inflammation

KW - Low-fat diet

KW - Maillard reaction products

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84949323103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949323103&partnerID=8YFLogxK

U2 - 10.1017/S0007114515003487

DO - 10.1017/S0007114515003487

M3 - Article

C2 - 26392152

AN - SCOPUS:84949323103

VL - 114

SP - 1797

EP - 1806

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 11

ER -