Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone

Sara G.M. Piccirillo, Inmaculada Spiteri, Andrea Sottoriva, Anestis Touloumis, Suzan Ber, Stephen J. Price, Richard Heywood, Nicola Jane Francis, Karen D. Howarth, Vincent P. Collins, Ashok R. Venkitaraman, Christina Curtis, John C. Marioni, Simon Tavaré, Colin Watts

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Glioblastoma, the most common and aggressive adult brain tumor, is characterized by extreme phenotypic diversity and treatment failure. Through fluorescence-guided resection, we identified fluorescent tissue in the sub-ependymal zone (SEZ) of patients with glioblastoma. Histologic analysis and genomic characterization revealed that the SEZ harbors malignant cells with tumor-initiating capacity, analogous to cells isolated from the fluorescent tumor mass (T). We observed resistance to supramaximal chemotherapy doses along with differential patterns of drug response between T and SEZ in the same tumor. Our results reveal novel insights into glioblastoma growth dynamics, with implications for understanding and limiting treatment resistance.

Original languageEnglish (US)
Pages (from-to)194-202
Number of pages9
JournalCancer Research
Volume75
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Piccirillo, S. G. M., Spiteri, I., Sottoriva, A., Touloumis, A., Ber, S., Price, S. J., ... Watts, C. (2015). Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone. Cancer Research, 75(1), 194-202. https://doi.org/10.1158/0008-5472.CAN-13-3131