Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone

Sara G.M. Piccirillo; Inmaculada Spiteri; Andrea Sottoriva; Anestis Touloumis; Suzan Ber; Stephen J. Price; Richard Heywood; Nicola Jane Francis; Karen D. Howarth; Vincent P. Collins; Ashok R. Venkitaraman; Christina Curtis; John C. Marioni; Simon Tavaré; Colin Watts

doi:10.1158/0008-5472.CAN-13-3131

Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone

Sara G.M. Piccirillo, Inmaculada Spiteri, Andrea Sottoriva, Anestis Touloumis, Suzan Ber, Stephen J. Price, Richard Heywood, Nicola Jane Francis, Karen D. Howarth, Vincent P. Collins, Ashok R. Venkitaraman, Christina Curtis, John C. Marioni, Simon Tavaré, Colin Watts

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Glioblastoma, the most common and aggressive adult brain tumor, is characterized by extreme phenotypic diversity and treatment failure. Through fluorescence-guided resection, we identified fluorescent tissue in the sub-ependymal zone (SEZ) of patients with glioblastoma. Histologic analysis and genomic characterization revealed that the SEZ harbors malignant cells with tumor-initiating capacity, analogous to cells isolated from the fluorescent tumor mass (T). We observed resistance to supramaximal chemotherapy doses along with differential patterns of drug response between T and SEZ in the same tumor. Our results reveal novel insights into glioblastoma growth dynamics, with implications for understanding and limiting treatment resistance.

Original language	English (US)
Pages (from-to)	194-202
Number of pages	9
Journal	Cancer research
Volume	75
Issue number	1
DOIs	https://doi.org/10.1158/0008-5472.CAN-13-3131
State	Published - Jan 1 2015

ASJC Scopus subject areas

Oncology
Cancer Research

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Piccirillo, S. G. M., Spiteri, I., Sottoriva, A., Touloumis, A., Ber, S., Price, S. J., Heywood, R., Francis, N. J., Howarth, K. D., Collins, V. P., Venkitaraman, A. R., Curtis, C., Marioni, J. C., Tavaré, S., & Watts, C. (2015). Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone. Cancer research, 75(1), 194-202. https://doi.org/10.1158/0008-5472.CAN-13-3131

Piccirillo, SGM, Spiteri, I, Sottoriva, A, Touloumis, A, Ber, S, Price, SJ, Heywood, R, Francis, NJ, Howarth, KD, Collins, VP, Venkitaraman, AR, Curtis, C, Marioni, JC, Tavaré, S & Watts, C 2015, 'Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone', Cancer research, vol. 75, no. 1, pp. 194-202. https://doi.org/10.1158/0008-5472.CAN-13-3131

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abstract = "Glioblastoma, the most common and aggressive adult brain tumor, is characterized by extreme phenotypic diversity and treatment failure. Through fluorescence-guided resection, we identified fluorescent tissue in the sub-ependymal zone (SEZ) of patients with glioblastoma. Histologic analysis and genomic characterization revealed that the SEZ harbors malignant cells with tumor-initiating capacity, analogous to cells isolated from the fluorescent tumor mass (T). We observed resistance to supramaximal chemotherapy doses along with differential patterns of drug response between T and SEZ in the same tumor. Our results reveal novel insights into glioblastoma growth dynamics, with implications for understanding and limiting treatment resistance.",

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AU - Sottoriva, Andrea

AU - Touloumis, Anestis

AU - Ber, Suzan

AU - Price, Stephen J.

AU - Heywood, Richard

AU - Francis, Nicola Jane

AU - Howarth, Karen D.

AU - Collins, Vincent P.

AU - Venkitaraman, Ashok R.

AU - Curtis, Christina

AU - Marioni, John C.

AU - Tavaré, Simon

AU - Watts, Colin

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AB - Glioblastoma, the most common and aggressive adult brain tumor, is characterized by extreme phenotypic diversity and treatment failure. Through fluorescence-guided resection, we identified fluorescent tissue in the sub-ependymal zone (SEZ) of patients with glioblastoma. Histologic analysis and genomic characterization revealed that the SEZ harbors malignant cells with tumor-initiating capacity, analogous to cells isolated from the fluorescent tumor mass (T). We observed resistance to supramaximal chemotherapy doses along with differential patterns of drug response between T and SEZ in the same tumor. Our results reveal novel insights into glioblastoma growth dynamics, with implications for understanding and limiting treatment resistance.

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Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone

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