Control of adenosylmethionine-dependent radical generation in biotin synthase: A kinetic and thermodynamic analysis of substrate binding to active and inactive forms of BioB

Medicine & Life Sciences

• biotin synthetase 100%
• S-Adenosylmethionine 65%
• Thermodynamics 60%
• Kinetics 36%
• desthiobiotin 17%
• Catalytic Domain 12%
• Sulfur 10%
• Enzymes 9%
• Hydrogen 5%
• Methionine 4%
• Escherichia coli 3%
• In Vitro Techniques 1%

Chemical Compounds

• Biotin 53%
• Molecular Cluster 27%
• Dethiobiotin 24%
• Monomer 16%
• Reductive Elimination Reaction 7%
• Methionine 7%
• Hydrogen Atom 6%
• Ultraviolet Spectrum 5%
• Reaction Stoichiometry 5%
• Kd 5%
• Probe 4%
• Environment 4%