Control of cardiac growth by histone acetylation/deacetylation

Johannes Backs, Eric N. Olson

Research output: Contribution to journalReview article

309 Scopus citations

Abstract

Histones control gene expression by modulating the structure of chromatin and the accessibility of regulatory DNA sequences to transcriptional activators and repressors. Posttranslational modifications of histones have been proposed to establish a "code" that determines patterns of cellular gene expression. Acetylation of histones by histone acetyltransferases stimulates gene expression by relaxing chromatin structure, allowing access of transcription factors to DNA, whereas deacetylation of histones by histone deacetylases promotes chromatin condensation and transcriptional repression. Recent studies demonstrate histone acetylation/deacetylation to be a nodal point for the control of cardiac growth and gene expression in response to acute and chronic stress stimuli. These findings suggest novel strategies for "transcriptional therapies" to control cardiac gene expression and function. Manipulation of histone modifying enzymes and the signaling pathways that impinge on them in the settings of pathological cardiac growth, remodeling, and heart failure represents an auspicious therapeutic approach.

Original languageEnglish (US)
Pages (from-to)15-24
Number of pages10
JournalCirculation research
Volume98
Issue number1
DOIs
StatePublished - Jan 1 2006

Keywords

  • Cardiac hypertrophy
  • Epigenetics
  • Gene expression
  • Histone acetyltransferase
  • Histone deacetylase

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Control of cardiac growth by histone acetylation/deacetylation'. Together they form a unique fingerprint.

  • Cite this