Control of cellular motility by neuropilin-mediated physical interactions

Xiaobo Li, Matthew W. Parker, Craig W.Vander Kooi

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

The neuropilin (Nrp) family consists of multifunctional cell surface receptors with critical roles in a number of different cell and tissue types. A core aspect of Nrp function is in ligand-dependent cellular migration, where it controls the multistep process of cellular motility through integration of ligand binding and receptor signaling. At a molecular level, the role of Nrp in migration is intimately connected to the control of adhesive interactions and cytoskeletal reorganization. Here, we review the physiological role of Nrp in cellular adhesion and motility in the cardiovascular and nervous systems. We also discuss the emerging pathological role of Nrp in tumor cell migration and metastasis, providing motivation for continued efforts toward developing Nrp inhibitors.

Original languageEnglish (US)
Pages (from-to)157-166
Number of pages10
JournalBiomolecular Concepts
Volume5
Issue number2
DOIs
StatePublished - May 31 2014

Keywords

  • VEGF
  • cellular motility
  • neuropilin
  • receptor signaling
  • semaphorin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Control of cellular motility by neuropilin-mediated physical interactions'. Together they form a unique fingerprint.

Cite this