Control of EGF receptor signaling by clathrin-mediated endocytosis

Amandio V. Vieira, Christophe Lamaze, Sandra L. Schmid

Research output: Contribution to journalArticle

762 Scopus citations

Abstract

Epidermal growth factor receptor (EGFR) signaling was analyzed in mammalian cells conditionally defective for receptor-mediated endocytosis. EGF-dependent cell proliferation was enhanced in endocytosis-defective cells. However, early EGF-dependent signaling events were not uniformly up- regulated. A subset of signal transducers required the normal endocytic trafficking of EGFR for full activation. Thus, endocytic trafficking of activated EGFR plays a critical role not only in attenuating EGFR signaling but also in establishing and controlling specific signaling pathways.

Original languageEnglish (US)
Pages (from-to)2086-2089
Number of pages4
JournalScience
Volume274
Issue number5295
DOIs
Publication statusPublished - Dec 20 1996

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