Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7

Shusheng Wang, Xiumin Li, Maribel Parra, Eric Verdin, Rhonda Bassel-Duby, Eric N. Olson

Research output: Contribution to journalArticle

148 Scopus citations

Abstract

VEGF has been shown to regulate endothelial cell (EC) proliferation and migration. However, the nuclear mediators of the actions of VEGF in ECs have not been fully defined. We show that VEGF induces the phosphorylation of three conserved serine residues in histone deacetylase 7 (HDAC7) via protein kinase D, which promotes nuclear export of HDAC7 and activation of VEGF-responsive genes in ECs. Expression of a signal-resistant HDAC7 mutant protein in ECs inhibits proliferation and migration in response to VEGF. These results demonstrate that phosphorylation of HDAC7 serves as a molecular switch to mediate VEGF signaling and endothelial function.

Original languageEnglish (US)
Pages (from-to)7738-7743
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume105
Issue number22
DOIs
StatePublished - Jun 3 2008

Keywords

  • Angiogenesis
  • Class II HDAC
  • MEF2
  • PKD1

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7'. Together they form a unique fingerprint.

  • Cite this