@article{a9872f4335e342fca1aeb54998dd37b5,
title = "Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene",
abstract = "Sexual orientation and courtship behavior in Drosophila are regulated by fruitless (fru), the first gene in a branch of the sex-determination hierarchy functioning specifically in the central nervous system (CNS). The phenotypes of new fru mutants encompass nearly all aspects of male sexual behavior. Alternative splicing of fru transcripts produces sex-specific proteins belonging to the BTB-ZF family of transcriptional regulators. The sex-specific fru products are produced in only about 500 of the 105 neurons that comprise the CNS. The properties of neurons expressing these fru products suggest that fru specifies the fates or activities of neurons that carry out higher order control functions to elicit and coordinate the activities comprising male courtship behavior.",
author = "Ryner, {Lisa C.} and Goodwin, {Stephen F.} and Castrillon, {Diego H.} and Anuranjan Anand and Adriana Villella and Baker, {Bruce S.} and Hall, {Jeffrey C.} and Taylor, {Barbara J.} and Wasserman, {Steven A.}",
note = "Funding Information: Correspondence should be addressed to B. S. B. We thank William Mattox, Ounissa A{\"i}t Ahmed, and Tim Hoey for many helpful discussions and advice on the work; Elizabeth Chen, Greg Bashaw, and Ignacio Marin for enthusiastically sharing their technical expertise; and Sue McConnell for her comments on the manuscript. The authors are also grateful to Sherry Alexander, Randy Bender, Barbara Berwald, Guennet Bohm, Merideth Humphries, Laura Knittel, and Christine O'Brien for excellent technical assistance. S. A. W. was supported by a fellowship from the Lucille P. Markey Charitable Trust. D. H. C. received predoctoral support through a Medical Scientist Training Grant from the National Institutes of Health, and L. C. R. received support from a Postdoctoral Training Grant from the NIH. This work was also supported by grants from the NIH (GM-21473 to J. C. H. and NS-33352 to B. B., J. C. H., and B. J. T.) and the National Science Foundation (IBN-9210785 to B. J. T.).",
year = "1996",
month = dec,
day = "13",
doi = "10.1016/S0092-8674(00)81802-4",
language = "English (US)",
volume = "87",
pages = "1079--1089",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "6",
}