TY - JOUR
T1 - Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C
AU - Lin, Qing
AU - Schwarz, John
AU - Bucana, Corazon
AU - Olson, Eric N.
PY - 1997/5/30
Y1 - 1997/5/30
N2 - Members of the myocyte enhancer factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, serum response factor)-box transcription factors bind an A-T-rich DNA sequence associated with muscle-specific genes. The murine MEF2C gene is expressed in heart precursor cells before formation of the linear heart tube. In mice homozygous for a null mutation of MEF2C, the heart tube did not undergo looping morphogenesis, the future right ventricle did not form, and a subset of cardiac muscle genes was not expressed. The absence of the right ventricular region of the mutant heart correlated wit h down- regulation of the dHAND gene, which encodes a basic helix-loop-helix transcription factor required for cardiac morphogenesis. Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development.
AB - Members of the myocyte enhancer factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, serum response factor)-box transcription factors bind an A-T-rich DNA sequence associated with muscle-specific genes. The murine MEF2C gene is expressed in heart precursor cells before formation of the linear heart tube. In mice homozygous for a null mutation of MEF2C, the heart tube did not undergo looping morphogenesis, the future right ventricle did not form, and a subset of cardiac muscle genes was not expressed. The absence of the right ventricular region of the mutant heart correlated wit h down- regulation of the dHAND gene, which encodes a basic helix-loop-helix transcription factor required for cardiac morphogenesis. Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development.
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U2 - 10.1126/science.276.5317.1404
DO - 10.1126/science.276.5317.1404
M3 - Article
C2 - 9162005
AN - SCOPUS:0030911475
SN - 0036-8075
VL - 276
SP - 1404
EP - 1407
JO - Science
JF - Science
IS - 5317
ER -