Control of smooth muscle development by the myocardin family of transcriptional coactivators

Da Zhi Wang, Eric N. Olson

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Differentiation of smooth muscle cells (SMCs) is accompanied by the transcriptional activation of an array of muscle-specific genes that confer the unique contractile and physiologic properties of this muscle cell type. The majority of smooth muscle genes are controlled by serum response factor (SRF), a widely expressed transcription factor that also regulates genes involved in cell proliferation. Myocardin and myocardin-related transcription factors (MRTFs) interact with SRF and potently stimulate SRF-dependent transcription. Gain- and loss-of-function experiments have shown myocardin to be sufficient and necessary for SMC differentiation. SMCs are highly plastic and can switch between differentiated and proliferative states in response to extracellular cues. Suppression of SMC differentiation by growth factor signaling is mediated, at least in part, by the displacement of myocardin from SRF by growth factor-dependent ternary complex factors. The association of SRF with myocardin and MRTFs provides a molecular basis for the activation of SMC genes by SRF and the responsiveness of the smooth muscle differentiation program to growth factor signaling.

Original languageEnglish (US)
Pages (from-to)558-566
Number of pages9
JournalCurrent Opinion in Genetics and Development
Volume14
Issue number5
DOIs
StatePublished - Oct 2004

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Serum Response Factor
Muscle Development
Smooth Muscle
Smooth Muscle Myocytes
Intercellular Signaling Peptides and Proteins
Transcription Factors
Genes
Cell Differentiation
Ternary Complex Factors
Muscle Cells
Transcriptional Activation
Plastics
Cues
myocardin
Cell Proliferation
Muscles

ASJC Scopus subject areas

  • Genetics

Cite this

Control of smooth muscle development by the myocardin family of transcriptional coactivators. / Wang, Da Zhi; Olson, Eric N.

In: Current Opinion in Genetics and Development, Vol. 14, No. 5, 10.2004, p. 558-566.

Research output: Contribution to journalArticle

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