TY - JOUR
T1 - Control of stress-dependent cardiac growth and gene expression by a microRNA
AU - Van Rooij, Eva
AU - Sutherland, Lillian B.
AU - Qi, Xiaoxia
AU - Richardson, James A
AU - Hill, Joseph A
AU - Olson, Eric N
PY - 2007/4/27
Y1 - 2007/4/27
N2 - The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of α-myosin heavy chain (αMHC) and up-regulation of βMHC, the primary contractile proteins of the heart. We found that a cardiac-specific microRNA (miR-208) encoded by an intron of the αMHC gene is required for cardiomyocyte hypertrophy, fibrosis, and expression of βMHC in response to stress and hypothyroidism. Thus, the αMHC gene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene expression in response to stress and hormonal signaling through miR-208.
AB - The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of α-myosin heavy chain (αMHC) and up-regulation of βMHC, the primary contractile proteins of the heart. We found that a cardiac-specific microRNA (miR-208) encoded by an intron of the αMHC gene is required for cardiomyocyte hypertrophy, fibrosis, and expression of βMHC in response to stress and hypothyroidism. Thus, the αMHC gene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene expression in response to stress and hormonal signaling through miR-208.
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U2 - 10.1126/science.1139089
DO - 10.1126/science.1139089
M3 - Article
C2 - 17379774
AN - SCOPUS:34247589595
VL - 316
SP - 575
EP - 579
JO - Science
JF - Science
SN - 0036-8075
IS - 5824
ER -