Control of stress-dependent cardiac growth and gene expression by a microRNA

Eva Van Rooij, Lillian B. Sutherland, Xiaoxia Qi, James A Richardson, Joseph A Hill, Eric N Olson

Research output: Contribution to journalArticle

1219 Scopus citations

Abstract

The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of α-myosin heavy chain (αMHC) and up-regulation of βMHC, the primary contractile proteins of the heart. We found that a cardiac-specific microRNA (miR-208) encoded by an intron of the αMHC gene is required for cardiomyocyte hypertrophy, fibrosis, and expression of βMHC in response to stress and hypothyroidism. Thus, the αMHC gene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene expression in response to stress and hormonal signaling through miR-208.

Original languageEnglish (US)
Pages (from-to)575-579
Number of pages5
JournalScience
Volume316
Issue number5824
DOIs
Publication statusPublished - Apr 27 2007

    Fingerprint

ASJC Scopus subject areas

  • General

Cite this