Controlled release from a composite silicone/hydrogel membrane

Zhibing Hu, Changjie Wang, Kevin D. Nelson, Robert C. Eberhart

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

To enhance the drug uptake and release capacity of silicone rubber (SR), N-isopropylacrylamide (NIPA) hydrogel particles have been incorporated into a SR membrane. The NIPA particles were thoroughly blended with uncured SR with a certain ratio at room temperature. The mixture was then cast in a Petri dish to 1 mm thickness and cured 10 hours at 90°C. The SR/NIPA composite gel can absorb water approximately equal to its dry weight. Brilliant blue, used as a mock drug, was loaded into the composite gel. Drug release increased exponentially to a final value that is temperature dependent: low at T> =34°C, and high at T< 34°C. This finding is because the hydrophobicity of NIPA changes with temperature. Pulsed release in response to temperature switching between 20 and 39°C has been achieved. Drug uptake and release capability strongly depends upon the structure of the composite gel. The optimal range of NIPA composition is between 75 and 87% by volume. In the cited range, the NIPA particles form an interconnected network that provides a channel for diffusion of drug solution. The SR/NIPA composite gel has promising attributes as a wound dressing and other uses.

Original languageEnglish (US)
Pages (from-to)431-434
Number of pages4
JournalASAIO Journal
Volume46
Issue number4
StatePublished - Jul 2000

Fingerprint

Hydrogel
Silicones
Hydrogels
Silicone Elastomers
Rubber
Membranes
Gels
Composite materials
Temperature
Pharmaceutical Preparations
Hydrophobicity
Particles (particulate matter)
Bandages
N-isopropylacrylamide
Hydrophobic and Hydrophilic Interactions
Chemical analysis
Weights and Measures
Water
Wounds and Injuries
Drug Liberation

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering

Cite this

Hu, Z., Wang, C., Nelson, K. D., & Eberhart, R. C. (2000). Controlled release from a composite silicone/hydrogel membrane. ASAIO Journal, 46(4), 431-434.

Controlled release from a composite silicone/hydrogel membrane. / Hu, Zhibing; Wang, Changjie; Nelson, Kevin D.; Eberhart, Robert C.

In: ASAIO Journal, Vol. 46, No. 4, 07.2000, p. 431-434.

Research output: Contribution to journalArticle

Hu, Z, Wang, C, Nelson, KD & Eberhart, RC 2000, 'Controlled release from a composite silicone/hydrogel membrane', ASAIO Journal, vol. 46, no. 4, pp. 431-434.
Hu Z, Wang C, Nelson KD, Eberhart RC. Controlled release from a composite silicone/hydrogel membrane. ASAIO Journal. 2000 Jul;46(4):431-434.
Hu, Zhibing ; Wang, Changjie ; Nelson, Kevin D. ; Eberhart, Robert C. / Controlled release from a composite silicone/hydrogel membrane. In: ASAIO Journal. 2000 ; Vol. 46, No. 4. pp. 431-434.
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