Controlling release from 3D printed medical devices using CLIP and drug-loaded liquid resins

Cameron J. Bloomquist, Michael B. Mecham, Mark D. Paradzinsky, Rima Janusziewicz, Samuel B. Warner, J. Christopher Luft, Sue J. Mecham, Andrew Z. Wang, Joseph M. DeSimone

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Mass customization along with the ability to generate designs using medical imaging data makes 3D printing an attractive method for the fabrication of patient-tailored drug and medical devices. Herein we describe the application of Continuous Liquid Interface Production (CLIP) as a method to fabricate biocompatible and drug-loaded devices with controlled release properties, using liquid resins containing active pharmaceutical ingredients (API). In this work, we characterize how the release kinetics of a model small molecule, rhodamine B-base (RhB), are affected by device geometry, network crosslink density, and the polymer composition of polycaprolactone- and poly (ethylene glycol)-based networks. To demonstrate the applicability of using API-loaded liquid resins with CLIP, the UV stability was evaluated for a panel of clinically-relevant small molecule drugs. Finally, select formulations were tested for biocompatibility, degradation and encapsulation of docetaxel (DTXL) and dexamethasone-acetate (DexAc). Formulations were shown to be biocompatible over the course of 175 days of in vitro degradation and the clinically-relevant drugs could be encapsulated and released in a controlled fashion. This study reveals the potential of the CLIP manufacturing platform to serve as a method for the fabrication of patient-specific medical and drug-delivery devices for personalized medicine.

Original languageEnglish (US)
Pages (from-to)9-23
Number of pages15
JournalJournal of Controlled Release
Volume278
DOIs
StatePublished - May 28 2018
Externally publishedYes

Keywords

  • 3D printing
  • Additive manufacturing
  • Continuous Liquid Interface Production
  • Crosslink density
  • Drug delivery
  • Medical device

ASJC Scopus subject areas

  • Pharmaceutical Science

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