Convenient preparation of α-trimethylsilyloxy- and α-hydroxystannanes from aldehydes

Rama K. Bhatt, Jianhua Ye, J. R. Falck

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Aldehydes, but not ketones, are converted to α-hydroxystannanes via the corresponding silyl ethers in good to excellent yields by Bu4NCN catalyzed addition of Bu3SnSiMe3 and hydrolytic isolation. Modest asymmetric induction was observed using a chiral quaternary ammonium cyanide catalyst.

Original languageEnglish (US)
Pages (from-to)4081-4084
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number24
DOIs
StatePublished - Jun 13 1994

Keywords

  • chiral induction
  • stannylhydrin
  • tin
  • trimethyl(tributylstannyl)silane

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Convenient preparation of α-trimethylsilyloxy- and α-hydroxystannanes from aldehydes'. Together they form a unique fingerprint.

Cite this