Abstract
The natural product saudin was found to induce hypoglycemia in mice and, therefore, could be an appealing lead structure for the development of new agents to treat diabetes. A diastereoselective tandem Stilleoxa- electrocyclization reaction has been developed which provides access to the core structure of saudin in a rapid and convergent manner. This new reaction has been extended to the convergent preparation of a series of polycyclic pyran systems. Progress has been made on the advancement of these complex pyran systems toward the natural product. A complete account of these synthetic efforts is presented.
Original language | English (US) |
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Pages (from-to) | 8357-8364 |
Number of pages | 8 |
Journal | Journal of Organic Chemistry |
Volume | 71 |
Issue number | 22 |
DOIs | |
State | Published - Oct 27 2006 |
ASJC Scopus subject areas
- Organic Chemistry