Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

Luis F. Parada, Hartmut Land, Robert A. Weinberg, David Wolf, Varda Rotter

Research output: Contribution to journalArticle

485 Scopus citations

Abstract

The protein p53 is highly expressed in a large variety of transformed cell types originating from diverse species. These include cells transformed by Simian virus 40 (SV40), adenovirus and Abelson virus, as well as a variety of chemically transformed cells1-6. Substantial amounts of p53 are also present in certain non-transformed cells, for example, some embryonic tissues7. The protein may be localized in different cellular compartments in normal and transformed cells8. The strong correlation between tumorigenicity and high levels of p53 suggests an important role of p53 in tumorigenesis. We report here experiments in which we have co-transfected the murine cellular gene encoding for p53 with a ras gene into primary rat embryo fibroblasts. Our results indicate that the p53-encoding gene can play a causal role in the conversion of normal fibroblasts into tumorigenic cells.

Original languageEnglish (US)
Pages (from-to)649-651
Number of pages3
JournalNature
Volume312
Issue number5995
DOIs
StatePublished - Dec 1 1984

ASJC Scopus subject areas

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    Parada, L. F., Land, H., Weinberg, R. A., Wolf, D., & Rotter, V. (1984). Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation. Nature, 312(5995), 649-651. https://doi.org/10.1038/312649a0