Coordinated transcription of key pathways in the mouse by the circadian clock

Satchidananda Panda, Marina P. Antoch, Brooke H. Miller, Andrew I. Su, Andrew B. Schook, Marty Straume, Peter G. Schultz, Steve A. Kay, Joseph S. Takahashi, John B. Hogenesch

Research output: Contribution to journalArticle

1664 Scopus citations

Abstract

In mammals, circadian control of physiology and behavior is driven by a master pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus. We have used gene expression profiling to identify cycling transcripts in the SCN and in the liver. Our analysis revealed ∼650 cycling transcripts and showed that the majority of these were specific to either the SCN or the liver. Genetic and genomic analysis suggests that a relatively small number of output genes are directly regulated by core oscillator components. Major processes regulated by the SCN and liver were found to be under circadian regulation. Importantly, rate-limiting steps in these various pathways were key sites of circadian control, highlighting the fundamental role that circadian clocks play in cellular and organismal physiology.

Original languageEnglish (US)
Pages (from-to)307-320
Number of pages14
JournalCell
Volume109
Issue number3
DOIs
StatePublished - May 3 2002

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. B., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002). Coordinated transcription of key pathways in the mouse by the circadian clock. Cell, 109(3), 307-320. https://doi.org/10.1016/S0092-8674(02)00722-5