Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine

Zhida Liu, Chang Zhou, Yan Qin, Zihao Wang, Luyao Wang, Xiuli Wei, Yinjian Zhou, Qicheng Li, Hang Zhou, Wenjun Wang, Yang Xin Fu, Mingzhao Zhu, Wei Liang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Although re-Activating cytotoxic T-cell (CTLs) response inside tumor tissues by checkpoint blockade has demonstrated great success in tumor immunotherapy, active induction of efficient endogenous CTL response by therapeutic vaccines has been largely hampered by inefficient cytosolic delivery of antigens and coordinated activation of dendritic cells (DCs) in lymph nodes. Here we show that polyethylene glycol-phosphatidylethanolamine (PEG-PE) micelles transform soluble peptides into α-helix to enable their efficient cytosolic delivery. The same PEG-PE micelles also serve as chaperon of TLR4 signaling to coordinate its adjuvant effect on the same DCs. Furthermore, these nanovaccines effectively target lymph node DCs. Thus, PEG-PE micelle vaccines program at multiple key aspects for inducing strong CTL responses and build up a foundation for combinational tumor therapy.

Original languageEnglish (US)
Article number17007
JournalCell Discovery
Volume3
DOIs
StatePublished - Apr 4 2017

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Cross-Priming
Micelles
Dendritic Cells
Tumors
Antigens
Vaccines
Lymph Nodes
Active Immunotherapy
Neoplasms
T-cells
Chemical activation
Tissue
T-Lymphocytes
Peptides
Therapeutics
phosphatidylethanolamine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine. / Liu, Zhida; Zhou, Chang; Qin, Yan; Wang, Zihao; Wang, Luyao; Wei, Xiuli; Zhou, Yinjian; Li, Qicheng; Zhou, Hang; Wang, Wenjun; Fu, Yang Xin; Zhu, Mingzhao; Liang, Wei.

In: Cell Discovery, Vol. 3, 17007, 04.04.2017.

Research output: Contribution to journalArticle

Liu, Z, Zhou, C, Qin, Y, Wang, Z, Wang, L, Wei, X, Zhou, Y, Li, Q, Zhou, H, Wang, W, Fu, YX, Zhu, M & Liang, W 2017, 'Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine', Cell Discovery, vol. 3, 17007. https://doi.org/10.1038/celldisc.2017.7
Liu, Zhida ; Zhou, Chang ; Qin, Yan ; Wang, Zihao ; Wang, Luyao ; Wei, Xiuli ; Zhou, Yinjian ; Li, Qicheng ; Zhou, Hang ; Wang, Wenjun ; Fu, Yang Xin ; Zhu, Mingzhao ; Liang, Wei. / Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine. In: Cell Discovery. 2017 ; Vol. 3.
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abstract = "Although re-Activating cytotoxic T-cell (CTLs) response inside tumor tissues by checkpoint blockade has demonstrated great success in tumor immunotherapy, active induction of efficient endogenous CTL response by therapeutic vaccines has been largely hampered by inefficient cytosolic delivery of antigens and coordinated activation of dendritic cells (DCs) in lymph nodes. Here we show that polyethylene glycol-phosphatidylethanolamine (PEG-PE) micelles transform soluble peptides into α-helix to enable their efficient cytosolic delivery. The same PEG-PE micelles also serve as chaperon of TLR4 signaling to coordinate its adjuvant effect on the same DCs. Furthermore, these nanovaccines effectively target lymph node DCs. Thus, PEG-PE micelle vaccines program at multiple key aspects for inducing strong CTL responses and build up a foundation for combinational tumor therapy.",
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AU - Wei, Xiuli

AU - Zhou, Yinjian

AU - Li, Qicheng

AU - Zhou, Hang

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AU - Fu, Yang Xin

AU - Zhu, Mingzhao

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