Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo

Donghoon M. Lee, Tony J.C. Harris

Research output: Contribution to journalComment/debatepeer-review

Abstract

Plasma membrane organization is under the control of cytoskeletal networks and endocytic mechanisms, and a growing literature is showing how closely these influences are interconnected. Here, we review how plasma membranes are formed around individual nuclei of the syncytial Drosophila embryo. Specifically, we outline the pathways that promote and maintain the growth of pseudocleavage and cellularization furrows, as well as specific pathways that keep furrow growth in check. This system has become important for studies of actin regulators, such as Rho1, Diaphanous, non-muscle myosin II and Arp2/3, and endocytic regulators, such as a cytohesin Arf- GEF (Steppke), clathrin, Amphiphysin and dynamin. More generally, it provides a model for understanding how cytoskeletal-endocytic cross-talk regulates the assembly of a cell.

Original languageEnglish (US)
Pages (from-to)68-74
Number of pages7
JournalBioarchitecture
Volume4
Issue number2
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Actin
  • Amphiphysin
  • Cellularization
  • Cytohesin
  • Cytoskeleton
  • Drosophila
  • Endocytosis
  • Plasma membrane
  • Rho1
  • Steppke

ASJC Scopus subject areas

  • Structural Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Coordinating the cytoskeleton and endocytosis for regulated plasma membrane growth in the early Drosophila embryo'. Together they form a unique fingerprint.

Cite this